3D Cell Culture Market 2021 Trends by Countries, Type and Applications Forecast To 2028

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The global 3D cell culture market size was valued at USD 1.5 billion in 2020 and is expected to grow at a compound annual growth rate (CAGR) of 10.7% during the forecast period. As 3D cultures can closely mimic a typical morphology and microarchitecture of organs, they are widely used in studies that require in vivo model systems to analyze the effects of a foreign drug over body tissues and organs.

A 3D cell culture is an in-vitro technique wherein the cells can grow in an artificially created environment. These environments closely resemble the architecture and functioning of the native tissue. 3D cell culture technique helps stimulate cell differentiation, proliferation, and migration by interacting with their three-dimensional surroundings as they would in the in-vivo environment. As 3D cell cultures can mimic the structure, activity, and microenvironment of the in-vivo tissues, this technique has varied applications in the fields of drug screening, regenerative medicine, stem cell therapies, cancer research and cell biology. The extracellular matrix in 3D cell cultures enables cell–cell communication by direct contact as in in-vivo environment by secreting cytokines and trophic factors. These factors are changed in a 2D environment that can significantly affect the cell–cell communication, which in turn can alter the cell morphology and proliferation. As 2D cultures cannot recapitulate the architecture and complex cellular matrices as in 3D cultures, this technique is gaining popularity in healthcare research sector. In addition, 3D cell cultures can provide results with improved efficiency and reduce the cost of overall R&D process.

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The high utility of 3-dimensional models for research about Covid-19 and respiratory diseases is expected to offer significant growth opportunities to the market. Airway and air-liquid interface organoids have been used as tools for the development and discovery of antiviral drugs, and as experimental virology platforms to study the immune responses and infectivity of SARS-CoV-2. Scaffold-based and scaffold-free techniques facilitate the bio-fabrication of realistic models that can be used for the development of novel therapeutics and vaccines against Covid-19.

Key Player Mentioned:

Merck KGaA

Thermo Fisher Scientific, Inc.

PromoCell GmbH

Greiner Bio One International GmbH

Corning, Inc.

3D Biomatrix



Product Segment Analysis:


  • Scaffold-based
  • Scaffold-free
  • Bioreactors

Application Segment Analysis:



Tissue Engineering & Immunohistochemistry

Drug Development

Stem Cell Research


Regional Segment Analysis:

  • North America
  • Europe
  • Asia Pacific
  • Latin America
  • Middle East & Africa

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North America led the global market in 2020 and accounted for the highest revenue share of over 43%. The region will retain its leading position throughout the forecast period on account of the availability of private and government funding for the development of advanced 3D cell culture models, high healthcare spending, and the presence of a large number of universities and research organizations investigating various stem cell-based approaches. In December 2020, researchers from Mayo Clinic and Terasaki Institute, U.S., developed visible hydrogels that can be used for the monitoring and control of hemorrhage.

COVID-19 Impact:

The outbreak of the COVID-19 pandemic has significantly increased the demand for antiviral medicines globally. The treatment of novel coronavirus has increased the demand for broad-spectrum Glucose to manage the disease. Remdesivir, favipiravir, oseltamivir, and other combination medicines are highly prescribed for the treatment of COVID-19. Moreover, governments are increasing funding to pharmaceutical companies to develop novel therapeutics against COVID-19. For instance, in June 2021, the U.S. government has announced an investment of more than USD 3 billion to fasten the discovery, development, and manufacturing of antiviral medicines for COVID-19 treatment. The rising incidence of disease coupled with increasing R&D will increase the demand for Glucose in the next 2 to 3 years.



KEY aspects covered in the report include:

  • The market size and industry growth rate of the global and regional market across various segments
  • The region or the sub-segment that is expected to drive the 3D Cell Culture market in the forecast period 2021-2028
  • Key companies operating in the global 3D Cell Culture market and their market share
  • The Factors that are estimated to drive the 3D Cell Culture Market growth
  • Key opportunities in the 3D Cell Culture market
  • Key technological advancements and market trends that shape the market



The study objectives of this report are:


  • To research global status, future forecasts, growth opportunities, key markets and key players.
  • To present the market development in us, Europe and China.
  • To strategically profile the key players and comprehensively analyze their development plan and methods.

About Grand View Research

Grand View Research, Inc. is a U.S. based market research and consulting company, registered in the State of California and headquartered in San Francisco. The company provides syndicated research reports, customized research reports, and consulting services. To help clients make informed business decisions, we offer market intelligence studies ensuring relevant and fact-based research across a range of industries, from technology to chemicals, materials and healthcare.


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