What is clinical research?
Clinical research refers to studies involving humans, health information, and human samples conducted to discover newer drugs and diagnostics to manage human diseases. Studies on human biospecimens act as the fundamental for any clinical studies. It helps the researchers to gain deeper insights into the health condition of the study subjects, disease nature, and pathogenesis. Also, in the clinical trial, human samples help to scrutinize the action and effectiveness of the investigational drug or device on humans.
Human biorepository and contemporary clinical research
For decades, biorepositories have played a vital role in clinical research. A Biorepository, also known as a biobank, is a dedicated establishment involved in collecting, processing, storing, and distributing human biospecimens for research. In clinical research, it helps achieve human specimens isolated from the human trial subjects during and after the close-out visit of the clinical trial. Nowadays, biorepositories supply high-quality human biospecimens on a large scale for in-vitro clinical research. Since these samples are well-tested and hyper-annotated with clinical data or health information, the samples can be used as in-vitro human models to learn in detail about the nature and biology of the disease.
Moreover, clinical research involving banked human biospecimens offers no risk to the human donors and helps the stakeholders to get rid of the risk and complications involved in the enrolment of clinical trial participants. Indeed, it directly cuts down the cost of research significantly. Definitely, this era marks the beginning of the human biospecimen revolution and a biorepository in the library of research on precious human biospecimens!
Biorepository best practices
Since the quality of banked human samples directly influences the research outcomes, the supply of good quality samples is crucial. To ensure this, it is essential to standardize the policies and procedures regarding sample handling and management. It is easy to perform quality control for a single-site trial with a single investigator but complicated with the regulation of muti-centric trials. Thus, in multi-centric clinical research, the entire process should be predefined with an IRB-approved protocol and standard operating procedure (SOP) to avoid deviations and discrepancies detrimental to research throughput. Also, strict quality should conduct for sample integrity. Moreover, the completeness and accuracy of annotated clinical information must be performed regularly. The samples with noted discrepancies must be replaced and appropriate root cause analysis and preventive actions must be executed. Besides, timely audits must be conducted to ensure compliance with the regulatory requirements and approved SOPs.
Central BioHub – a compliant gateway to top-quality human biospecimens
Central BioHub offers the most innovative online marketplace for buying and selling human biospecimens online. Central BioHub leverage to bring high-quality, hyper-annotated human samples from world-class biorepository labs. Explore the live inventory: https://centralbiohub.de/
With the mission to end the tedious biospecimen procurement, Central BioHub accelerates drug and diagnostic research worldwide. Learn more about their next-generation marketplace here: https://centralbiohub.de/blogs/biorepositories. Hurry up and let the precious human samples find their place in your research project.
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