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Are polypills and population-based treatment the next big things?

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Cardiovascular disease (CVD), such as heart attack and stroke, is a leading cause of death and disability in the US. High blood pressure and high cholesterol are major risk factors for CVD, and even though they are quite common and highly treatable, they tend to be undertreated. This is especially true among those who are poor or members of a minority. It’s estimated that thousands of lives could be saved each year if more people with high blood pressure and high cholesterol received treatment for these conditions.

The appeal of the polypill

One reason that high blood pressure and high cholesterol are poorly treated is that medications prescribed to treat them aren’t reliably taken as prescribed (the common medical expression for this is poor medication adherence). Among the most important reasons for this are that these conditions usually cause no symptoms, it’s hard to remember to take multiple medications or multiple doses of medications each day, medications may cause side effects, and they may be expensive.

One potential way to improve medication adherence is to combine one or more medications into a single pill, or polypill. Advantages to this approach include:

  • Lower doses of each medication may be needed, possibly reducing the incidence of troublesome side effects.
  • Multiple medications (in low doses) may be more effective than higher doses of a single medication.
  • Fewer doses are easier to remember.
  • Depending on the specific medications and doses, a polypill could be less expensive than taking several individual medications.
  • Fewer pills and lower doses of medications may require fewer office visits, blood tests, and other monitoring.

Potential downsides of the polypill

While the potential advantages of a polypill are clear, they could be outweighed by their downsides, including:

  • Side effects. Taking multiple medications, even at low doses, may lead to higher rates of side effects. If a side effect does occur, it may be impossible to know which of the medicines in the polypill is responsible.
  • Drug interactions. When combined, medications can interact, causing serious problems such as too much or too little potency, allergic reactions, or combined side effects.
  • Overtreatment. Some people need only one or two medications to treat a condition; polypills may provide more medication than is needed.
  • Cost. A polypill may be more expensive than the individual medications they contain.
  • Less dosing flexibility. Polypills have fixed doses of several medications, so it may not be possible to adjust the dose of one medication without adjusting them all.

A new polypill study focuses on those who might benefit the most

A recent study in the New England Journal of Medicine reported positive results for people taking a polypill to lower blood pressure and cholesterol. Researchers enrolled 303 people without known CVD but who were considered high-risk based on being members of a minority and having low income: 96% were African American and 75% had incomes less than $15,000/year.

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Written by Shobha

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