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Gender differences in cardiovascular disease: Women are less likely to be prescribed certain heart medications

Cardiovascular disease (CVD) is the leading killer of both women and men in the US. Despite the significant impact CVD has on women, awareness and education for women’s heart disease has historically been low. A recent study, based on data from over two million patients, suggests that women were less likely to be prescribed aspirin, statins, and certain blood pressure medications compared to men.

CVD is a group of diseases involving the heart or blood vessels. It includes high blood pressure (hypertension), coronary artery disease, heart attacks, heart failure, heart valve problems, and abnormal heart rhythms. CVD can look different in men and women, potentially requiring different approaches to diagnosis and treatment and leading to differences in outcomes.

Gender differences in CVD

A general lack of awareness of women’s heart disease may lead to doctors or patients missing heart attacks in women or delaying their diagnosis. For example, while the frequency of CVD tends to be lower in women before menopause than in men, the frequency dramatically increases after menopause, when it accounts for approximately one out of every three deaths in women.

In addition, many of the “classic” signs and symptoms of CVD are based on medical research largely performed in men. For example, many think of chest pain as a typical symptom of a heart attack. But while both men and women can experience chest pain, women are more likely to experience atypical symptoms such as nausea or vomiting, shortness of breath, dizziness, or no symptoms at all. What’s more, 64% of women who die suddenly of coronary heart disease had no previous symptoms.

Underlying physiological differences in CVD in men and women may also result in less aggressive diagnosis and treatment in women. Men more commonly develop blockages of the major heart arteries, whereas women more commonly have disease of the small heart arteries (microvascular dysfunction), which can make treatment more challenging. And studies (like this one and this one) suggest that women get lifesaving procedures, such as heart catheterizations, less frequently, and later during the course of a heart attack, than men.

Treatments to control and prevent CVD

Many medications are commonly used to both prevent CVD before it occurs and to prevent existing disease from getting worse.

  • Statins: a family of cholesterol-lowering medications
  • Aspirin: one baby aspirin (81 mg) per day is widely recommended for people with established coronary artery disease or those who have had a heart attack
  • Blood pressure medications: several classes of blood pressure medications exist, including ACE inhibitors, diuretics, beta bloc

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Written by Shobha

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