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Chemical Products Clarithromycin Description

Clarithromycin is a macrolide antibiotic and a CYP3A4 inhibitor.Target: Antibacterial; CYP3A4Clarithromycin is a macrolide antibiotic used to treat pharyngitis, tonsillitis, acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, pneumonia (especially atypical pneumonias associated with Chlamydophila pneumoniae), skin and skin structure infections. Clarithromycin prevents bacteria from growing by interfering with their protein synthesis. It binds to the subunit 50S

Chemical Products Clarithromycin Basic Attributes

CAS No:81103-11-9

Molecular Formula :C38H69NO13

Molecular Mass :747.95300

Exact Mass :747.47700

PSA :182.91000

LogP :3.2

EINECS :617-200-4


H-bond Acceptor :14

H-bond Donor :4

SP3 :0.95

RBN :8

Chemical Products Clarithromycin Characteristics

Density :1.18 g/cm3

Melting Point :217-220ºC

Bolling Point :805.5ºC at 760 mmHg

Flash Point :440.9ºC

Refractive Index :1.526

Solubility :99.48mg/L(20 ºC)

Storage Condition :Store only in original container. Keep container tightly closed.

Vapor Pressure :2.32X10-25 mm Hg at 25 deg C (est)

Stability :Store in Freezer

Chemical Products Clarithromycin Safety Information

HS Code :29419000

UN No. :NONH for all modes of transport

WGK_Germany :3

Risk Code :R22

Safety Instructions :S26; S36

RTECS No. :KF4997000

Dangerous Mark :Xi; Xn

P Code :P301 + P312 + P330

Hazard Statements :H302

Toxicity :LD50 in male, female mice, male, female rats (mg/kg): 2740, 2700, 3470, 2700 orally, 1030, 850, 669, 753 i.p., >5000 all s.c. (Abe)

Chemical Products Clarithromycin Product Usage

1. A semi-synthetic macrolide antibiotic. A derivative of erythromycin

2. Antibacterial

3. Clarithromycin is a semi-synthetic macrolide antibiotic. Clarithromycin is a derivative of Erythromycin (E650000).

4. Clarithromycin (6-methoxyerythromycin) is a macrolide antibiotic active against a broad range of Gram positive bacteria. Clarithromycin was designed to enhance acid stability and improve oral bioavailability compared with erythromycin which is highly unstable to acidic conditions, undergoing a series of internal ketalisations between the 9-keto moiety and alcohols at C6 and C11. Omura and colleagues found that protection of the labile 6-OH group by methylation provided a simple but elegant solution.

5. Labeled Clarithromycin, intended for use as an internal standard for the quantification of Clarithromycin by GC- or LC-mass spectrometry.

6. A macrolide antibiotic and protein synthesis inhibitor

Chemical Products Clarithromycin Material and Products

Material :

Clarithromycin Impurity Q (10 mg) (N-oxide clarithromycin), MethylIodide, Erythromycin, Benzylchloroformate, Tetrahydrofuran, Formaldehyde, ClarithroMycin 9-OxiMe, Tetrahydropyran, Erythromycin-9-oxime, Erythromycin, 6-O-Methyl-2′,4′-Bis-O-(Trimethylsilyl)-, 9-[O-(1-Methoxy-1-Methylethyl)Oxime]

Products :

2,5-dimethylcyclopentan-1-one, Telithromycin, (10E)-10,11-Didehydro-11-deoxy-6-O-MethylerythroMycin, 2,2-DIMETHYLCYCLOPENTANONE


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