What are Analytical Standards?
Standards contain a known concentration of an analyte which provides a credential to decide the unknown concentration or to calibrate analytical instruments. A scientist performs analytical tests by using reference standards to determine qualitative and quantitative data, calibrators, and performance standards and this purity and quality of reference standards help to reach a scientifically valid result.
The accuracy of an analytical measurement helps to measure the true value. It requires calibration of the analytical standard.
A primary standard is extremely stable, pure, and has a high molecular weight. Some primary standards are:
- potassium hydrogen iodate: KH(IO3)2, mol wt. = 389.92 g/mol
- potassium hydrogen phthalate (KHP): KHC8H4O4, mol wt. = 204.23 g/mol
- potassium dichromate: K2Cr2O7, mol wt. = 294.19 g/mol
A secondary standard is used in the laboratory for a specific analysis. Some examples of secondary standards for chemical composition are:
- sulfur in fossil fuels
- elements used in iron, steel, and other metal alloys
- polychlorinated biphenyls (PCBs) in oils
- elements in foods and beverages.
Metrological Traceability and SI Units for Reference Materials
The SI, or International System of Units, explains that the primary set of seven units of measurement is used to create further SI units. For reference materials, the mole and kilogram are the two most used metrological traceability units. Metrological traceability is one of the most significant features of reference material dimensioning. In metrological traceability, the SI unit is the initial measuring term.
Different types of reference standard materials and their uses
- Essay: It is used to determine APIs and salts
- Degradation Products: Used to identify quantitate degradation products
- Process Impurities: To identify quantitate process-related compounds
- Resolution Standard: To determine the impurity method
- Metabolites standard: To identify quantitated substances through the metabolic process.
Analytical Standards Market Outlook
The Global analytical standards market was valued at USD 1.2 billion in 2021 but it will be projected to grow to USD 1.7 billion by 2025 at a CACR of 6.3%. The Global analytical standards will offer food quality and safety, and greater regulatory emphasis on pollution monitoring. These analytical standards are used to make sure the presence of specific components in the compound and perform a test or an evaluation of an analyzer. There are several methods of analytical standards including bioanalytical testing, raw material testing, stability testing and etc. Analytical testing has a major role to understand the physical and chemical stability of drug molecules.
Conclusion
Reference materials ensure testing accuracy by assisting with modifications to measuring systems, methodological validation, and quality control procedures. The range of reference materials is vast, and it might be difficult to distinguish between analytical certifications, metrological traceability, CRM or certified reference materials, and reference materials of many different characteristics and ideas.
