1. How To

How to select a right High Pressure Homogenizer

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Choosing the Right High-Pressure Homogenizer: A Guide


High-pressure homogenizers are vital tools in various industries, ensuring efficient processing and top-notch product quality. Selecting the perfect high-pressure homogenizer involves several key considerations for optimal results. Here's a concise guide on how to make the right choice:


  1. High-Pressure Generator Selection:


When it comes to high-pressure generators, favor a cylinder with an intensifier over a direct-drive mechanism. Higher pressure levels offer advantages like reduced frequency, fewer pressure fluctuations, improved product quality, and enhanced equipment durability. For instance, Genizer's laboratory high-pressure homogenizer, Nanogenizer3, operates at 30,000 psi with minimal fluctuations of less than 10 Hz, as opposed to the 60 Hz typical of regular homogenizers.

NanoGenizer High Pressure Homogenizer


ceramic piston


Ceramic piston


  1. Homogenization Components:


Homogenization chambers play a pivotal role in achieving optimal results. Different inner constructions of these chambers lead to varying outcomes and applications. When selecting a suitable homogenizer, consider both performance and cost. In general, first-generation homogenization chambers are more economical but offer moderate performance. Second-generation chambers provide superior results but come at a higher cost. Genizer's interaction chamber with a cooling system is ideal for thermally unstable biological and pharmaceutical products.


Homogenization chamber performance comparison




First generation Figure A & Figure B Impact type

Second generation Figure C Interaction type






Scale-up guarantee




Enhance performance

Dual stage

Single stage


Optimize performance




Biological applications





  1. Maximum Homogenizing Pressure:


Higher homogenizing pressure generally results in better quality. It leads to smaller and more uniform particle sizes, making the process more efficient. Higher pressure also allows for processing a wider range of samples. Emulsions typically require 20,000 psi for a particle size of 100 nm, while suspensions often need at least 45,000 psi to achieve a nanoscale effect. However, high temperatures can affect the process, so 30,000 psi is the maximum pressure without a cooling system. Genizer's ultra-high pressure diamond interaction chamber with cooling capabilities can handle pressures up to 60,000 psi.


  1. Ensuring Product Uniformity:


Uniform particle size distribution is critical in production processes, especially in pharmaceutical emulsions. Regulatory bodies like the US Pharmacopeia (USP) have specific requirements for particle size distribution. Interaction chambers typically produce more uniform distributions compared to impact valve homogenizers.


By considering these factors, you can confidently select the right high-pressure homogenizer, such as the Genizer High-Pressure Homogenizer, to meet your specific processing needs and quality standards.

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