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Levaquin, the brand name for Levofloxacin, is a fluoroquinolone antibiotic that treats a variety of bacterial infections and has been used to treat anthrax exposure and plague. Janssen Pharmaceuticals, a Johnson & Johnson subsidiary, marketed levaquin until its discontinuation in 2017 due to safety concerns and growing antibiotic resistance. Despite its effectiveness, Levaquin has been linked to serious side effects, prompting thousands of lawsuits against its manufacturers.

Common adverse effects include nausea and headaches, but more severe issues such as tendonitis, peripheral neuropathy, and aortic aneurysms have been reported. The latter two conditions prompted FDA warnings, with peripheral neuropathy warnings coming in 2013 and an update in 2016 to include risks of muscle and nerve damage. The FDA has also issued black box warnings, the strictest labels for prescription drugs, advising Levaquin’s use only when no other options are available.

The most significant legal actions concern tendon ruptures, often involving the Achilles tendon, and neurological damage. A 2015 JAMA Internal Medicine study suggested fluoroquinolones could double the risk of aortic aneurysm and dissection, serious conditions that can lead to internal bleeding or death. Lawsuits allege that manufacturers failed to provide adequate warnings about these risks, despite some patients experiencing persistent symptoms long after stopping the medication. The FDA's increased warnings have highlighted potential severe drops in blood sugar and mental health effects.

In 2010, a Levaquin lawsuit resulted in a $1.8 million award to the plaintiff for tendon injuries, leading to the resolution of 845 cases. However, many claims remain unresolved, especially those involving Stevens-Johnson syndrome (SJS) and peripheral neuropathy. Plaintiffs argue that the warnings did not sufficiently detail the severity and frequency of side effects.

Individuals who suffered adverse effects from Levaquin may be eligible for legal action, with medical records being essential to support claims. Experienced attorneys can assess cases and assist in seeking compensation. The legal challenges against Levaquin underscore the importance of pharmaceutical companies disclosing the full risks of their products. While Levaquin is no longer produced, its legacy continues as it sparks discussions on medication risks, urging the public and medical professionals to stay informed about drug safety.

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