Glutamate is important in learning and memory, but excess activity of glutamate can lead to damage and death of brain cells, which worsens cognitive symptoms in Alzheimer's disease. By regulating the activity of glutamate, Memantine can help protect brain cells from damage and improve cognitive function in patients with Alzheimer's disease.

Memantine is also important in the treatment of Alzheimer's disease because it is effective in managing the moderate to severe stages of the disease. While cholinesterase inhibitors are typically used in the mild to moderate stages of the disease, Memantine is used in the moderate to severe stages when symptoms are more severe and less responsive to other treatments.

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