Armodafinil is a Nootropic medication chip used to enhance wakefulness and alertness, resulting in enhanced mental function overall.
Since 2007, the FDA has authorized the sale of armodafinil under the brand names Waklert and NuVigil as prescription medicine in the United States.
According to Armodafinil's manufacturers, Cephalon, Inc., around 1.6 million people have purchased the drug in the past three years.
It happened before that you buy Modafinil or even better yet, that you buy Modafinil online? Good news! The drug is a derivative of Modafinil with many of the same benefits, but with a somewhat higher potency.
Which one you choose to use is a question of personal preference, however many individuals believe that Armodafinil is more effective and lasts longer.
The medicinal applications of Armodafinil are broad, but the nootropic community also utilizes it off-label as a cognitive enhancer.
HISTORY OF ARMODAFINIL
Before you buy Modafinil or Armodafinil, you should know their History! Armodafinil is a eugeroic, or a chemical that promotes wakefulness. It is closely linked to the 1970s-era compounds Adrafinil and Modafinil.
The French pharmaceutical company Laboratoires Lafon produced a series of sulfinyl benzhydryl chemicals in 1974. A single of these substances was Adrafinil. Modafinil was discovered through testing to identify how Adrafinil functions in the body.
Adrafinil, after ingested, travels via the bloodstream to the liver, where it is broken down into Modafinilic acid and Modafinil. Modafinil is the primary active ingredient responsible for Adrafinil's effects.
In early animal studies, both Adrafinil and Modafinil exhibited similar stimulant effects, including an increase in alertness and locomotion. Due to these effects, they were initially evaluated for the treatment of the sleep disorder narcolepsy in humans.
Both Modafinil and Adrafinil were found to considerably reduce narcolepsy-related excessive daytime sleepiness and enhance wakefulness. In France, Adrafinil was licensed for this use in 1986, and Modafinil in 1994. In 1998, Modafinil was also authorized in the United States.
As soon as it passed testing and approval and it became possible to synthesize Modafinil on its own, the need for Adrafinil decreased. Eventually, production of this less powerful chemical was discontinued (although it is now made today by other manufacturers).
Cephalon Inc. acquired Lafon Laboratories in 2001. Cephalon continued to manufacture Provigil, the original brand of Modafinil developed by Lafon scientists.
A few years before the expiration of Provigil's patent exclusivity, Cephalon scientists were entrusted with generating a new form of the substance that would assist the company preserve its market dominance. This resulted in the creation of armodafinil.
Modafinil consists of two mirror-image stereoisomers with the same chemical structure (like a left and right hand). They are known as enantiomers, and only R-Modafinil and S-Modafinil exist.
In compounds such as this, one of the enantiomers may be responsible for the majority of the actions, while the other may be mostly inactive or induce more adverse effects. The R-enantiomer is the more pharmacologically active, stable, and long-acting of the two isomers, according to study.
Scientists have developed Armodafinil, an enantiopure form of Modafinil, by extracting the R-enantiomer alone from R-Modafinil. Cephalon's marketed version of Armodafinil was and is known as Nuvigil.
Cephalon was purchased by Teva Pharmaceutical Industries in 2011. Cephalon continues to operate as a subsidiary of Teva, producing the original branded versions of Modafinil and Armodafinil, Provigil and Nuvigil, respectively.
EFFECTS OF ARMODAFINIL
The initial objective of creating Armodafinil was to create a more potent form of Modafinil for use as wakefulness enhancer in individuals with excessive daytime sleepiness.
It can be used to treat apnea/hypopnea syndrome, narcolepsy, and to increase alertness in patients with shift work sleep disorders and other irregular sleepers.
Despite the fact that early clinical trials were equivocal, it is still believed that this drug may be effective in the treatment of attention deficit hyperactivity disorder (ADHD), depression, and schizophrenia.
Although the FDA has refused to approve this supplement as a cure for jet lag, many experts continue to feel it is useful.
One of the reasons why Armodafinil has become so popular is because it gives a potent energy boost without the unpleasant side effects that other medicines might produce.
Armodafinil has a fundamentally different effect than coffee and other typical stimulants. The majority of users report feeling a more 'natural' level of wakefulness and alertness that lasts longer and enables them to be more focused and productive.
As with typical stimulants, the majority of users will not feel jitters, anxiety, restlessness, or changes in blood pressure with comparable frequency.
Numerous researchers hypothesize that armodafinil modifies how the brain perceives or conveys weariness to the rest of the body.
As with its forerunner Modafinil, the precise mechanism of action of Armodafinil is yet uncertain. However, similar to Modafinil, Armodafinil has been reported to interact with numerous neurotransmitters in the brain and central nervous system, including Dopamine, Serotonin, Epinephrine (Adrenaline), Noradrenaline (Norepinephrine), Orexine (Hypocretin), and Histamine.
Armodafinil has been reported to impair both the transport and reuptake of dopamine. This increases Dopamine circulation.
Although it has not been directly examined with Armodafinil, it is believed that many of Modafinil's effects are a result of its interactions with orexin and Histamine. It is reasonable to generalize the effects of Modafinil to those of Armodafinil, as the two substances operate in a manner that is extremely similar.
Modafinil stimulates orexin and neurons that secrete orexin in the brain. Orexin is a neuropeptide that influences arousal, excitement, and hunger. Orexin promotes the release of Histamine, a neurotransmitter with the same physiological effects.
It is considered that Modafinil and Armodafinil have the greatest stimulating effects as a result of their actions.
ARMODAFINIL & NARCOLEPSY
Armodafinil is used to treat severe sleep disturbances in the same manner that Modafinil was previously used for. The Food and Medicine Administration (FDA) has designated armodafinil as the sole Schedule IV prescription drug approved as a treatment for narcolepsy, shift work sleep disorders, and as an adjunctive treatment for obstructive apnea/hypopnea syndrome.
Narcolepsy is a neurological sleep condition characterized by extreme daytime sleepiness and unpredictable, frequently unscheduled onsets of sleep during the day. In a number of placebo-controlled, double-blind clinical trials, Modafinil and Armodafinil were found to dramatically enhance wakefulness and decrease excessive daytime drowsiness in narcoleptics.
Patients in one study received either a placebo or Armodafinil. On the Maintenance of Wakefulness Test, it was observed that Armodafinil patients had significantly better mean sleep latency times compared to placebo patients.
Some people acquire major work sleep problems when their job schedule demands them to be awake and working at night and sleeping during the day, either constantly or intermittently. This results in excessive drowsiness when awake throughout the night and might lead to sleeplessness during the day.
In one study, patients taking Armodafinil had significantly better average sleep latency periods on the Sleep Latency Test compared to patients receiving placebo. On the Epworth Tiredness Scale, patients reported less sleepiness during night shifts, laboratory testing, and night commutes.
The medical condition obstructive apnea/hypopnea syndrome affects breathing during sleep. The most common treatment for this illness is nighttime use of a nasal continuous positive airway pressure (nCPAP) machine. Some individuals still experience severe daytime sleepiness despite receiving effective treatment, and Armodafinil is prescribed in these instances. In one study, Armodafinil appeared to significantly enhance baseline mean sleep latency times on waking tests compared to placebo. The patient's perception of wakefulness increased, while weariness decreased.What’s good to know, finally, is that you can buy Modafinil online and Armodafinil as well!