jerrycret668's articles

The latest clinical trial data on the allogeneic stem cell therapy VX-880 for type I diabetes was just revealed by Vertex, one of the world's pharmaceutical giants. The patient's insulin production function was restored on day 90 of VX-880 treatment, and his daily insulin requirement was reduced by 91%, while blood glucose control was significantly […]
Herpes viruses appear to be a little more low-key than the SARS-CoV-2 that is currently wreaking havoc around the globe, as well as more recognizable viruses like HIV and hepatitis B. Their activity, on the other hand, is anything but low-key, and they are possibly the most “successful” infections ever discovered. Herpes viruses are DNA viruses […]
Recently, Cleveland Clinic researchers formally initiated a clinical trial of a breast cancer vaccine aimed to prevent triple-negative breast cancer, which could become the first breast cancer vaccine ever developed. The clinical trial is based on a 2010 study published in Nature Medicine. Breast cancer, the most common cancer among women, has overtaken lung cancer as the world's […]
Remember when we previously identified exactly what the protective power of the Pfizer vaccine against COVID-19 was? CNBC reported on the newest data provided by the Israeli Ministry of Health on July 23, 2021, which are doubly concerning. According to the investigation, the Pfizer/BioNTech mRNA vaccine provides only 39% protection against infection with symptomatic COVID-19 […]
The SARS-CoV-2 causing COVID-19 epidemic has been worldwide in scope since the end of 2019, with high global mortality rates, and has led to a global public health crisis. The clinical symptoms of COVID-19 are diverse, ranging from fever, malaise, and dry cough to dyspnea, from mild pneumonia to acute lung injury (ALI) and acute […]
Nanotechnology advancements have enabled the design of drugs that can be absorbed or bonded on the surface of nanoparticles, encapsulated in the core, or dissolved inside the particle matrix, allowing for the introduction of targeted, safe, i.e., effective nanoparticle (NP) drug formulations. Nanodrug delivery methods have the ability to improve hydrophobic drug solubility, enhance drug biodistribution and […]
Since the emergence of the Delta variant of the SARS-CoV-2 in many parts of the world, the number of so-called “breakthrough infections”—SARS-CoV-2 infection despite vaccination—has increased. Although the overall number is small, it raises questions about the efficacy of vaccine protection: Can the existing COVID-19 vaccines provide broad protection against the newly emerging mutant strains? […]
The structural and functional heterogeneity of therapeutic antibodies (IgG type) is achieved by post-translational modifications (PTM), among which the glycosylation of antibody Fc is the most heterogeneous one that can affect the stability of the molecule and its interaction with the Fc receptor in vivo. Thus, glycan distribution can influence a drug's mechanism of action, as well as […]

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