Indaflex Crema is used as a topical cream to help treat inflammation. You can apply it on affected areas three to four times a day. The main ingredient is Indometacina, which is a potent prostaglandin inhibitor and tocolitic agent. It is non-steroid and also has analgesic properties. It is used for many types of inflammation, including traumatic or local inflammation.
GI bleeding
Indaflex crema is used to treat bleeding in the gastrointestinal tract. It should be taken with or after food. GI bleeding is a serious condition that can lead to death, particularly in older adults. The risk of developing gastrointestinal bleeding also increases with a history of peptic ulcers or NSAID therapy. In addition, patients with liver disease and coagulopathy are also at a greater risk.
Indaflex is absorbed rapidly from the gastrointestinal tract and reaches its peak plasma concentrations within 0.5 to two hours of administration. About 90% of the drug is bound to plasma proteins. It is then distributed into other tissues, including the CNS and placenta. In addition, it has been detected in breast milk. Indaflex is metabolised by the liver through glucuronidation and enterohepatic circulation, and it is excreted mostly in the urine. It is also excreted in small amounts in feces and milk.
Hyperkalaemia
NSAIDs, including indaflex crema, can cause severe skin reactions such as exfoliative dermatitis, Stevens-Johnson syndrome, or toxic epidermal necrolysis. Patients should be monitored closely for the onset of a reaction, and discontinue the medication if symptoms persist. Patients should also be alert for the signs and symptoms of hyperkalaemia and discontinue the drug if hyperkalaemia develops.
Indaflex is absorbed rapidly from the gastrointestinal tract, reaching plasma concentrations in 0.5 to 2 hours. Approximately 90% of the drug is bound to plasma proteins. After administration, it is metabolised in the liver through glucuronidation and enterohepatic circulation, with a half-life of three to 11 hours. It is primarily excreted in the urine, with some excretion occurring in feces and milk.
Epistaxis
Indaflex is a nonsteroidal anti-inflammatory drug (NSAID) indicated for the treatment of osteoarthritis, rheumatoid arthritis, degenerative joint disease of the hip, and acute musculoskeletal disorders. It is also approved for the treatment of pain and oedema following orthopaedic procedures. It is also used to treat primary dysmenorrhoea.
Indaflex can cause gastrointestinal side effects, including ulceration and bleeding. It should be avoided in pregnant women and those who are breastfeeding. It should also not be used by women who are taking anticoagulants or concomitant medications. In addition, concomitant use of Indaflex with NSAIDs and salicylates increases the risk of gastrointestinal toxicity.
Hepatotoxicity
Indaflex crema may have an adverse effect on the liver. It is important to consult a physician if liver damage occurs. It may also cause bleeding or affect the utility of diagnostic signs. Patients should discontinue this medicine if they develop these adverse reactions. This drug should not be used for prolonged periods in people with renal failure.
Although the risk of hepatotoxicity is low, this medication is not safe for pregnant women and should be used with caution. It may increase the risk of gastrointestinal bleeding and the development of aseptic meningitis. Indaflex is also suspected of impairing female fertility, and withdrawal should be considered if a patient becomes infertile while taking it.
Premature closure of fetal ductus arteriosus
During pregnancy, a ductus arteriosus diverts fetal blood away from the lungs. This is important because it helps fetus breathe by relieving the pressure of fluid-filled lungs. If it closes prematurely, the fetus can suffer pulmonary hypertension and even die. While this is a rare occurrence, it is still dangerous.
Premature closure of the fetal ductus arteriosis can result from the use of indomethacin or other NSAIDs during pregnancy. It is also important to note that Indaflex is not to be taken by pregnant women who are taking other NSAIDs or salicylates. The concomitant use of Indaflex and other NSAIDs can increase gastrointestinal toxicity and result in less efficacy.