Top 10 Knee Injection Clinics in the USA
Are aching knees slowing you down? Whether you're dealing with arthritis, injury, or everyday wear and tear, a knee injection might be the non-surgical solution you've been looking for. These injections can ease inflammation, restore mobility, and help you avoid more invasive treatments like surgery.
Across the U.S., numerous clinics specialize in different types of knee injection therapies—from corticosteroids to hyaluronic acid and PRP (Platelet-Rich Plasma). But not all clinics are created equal. In this list, we’re highlighting the top 10 knee injection clinics in the USA—with Menz Clinic in Orlando proudly leading the pack.
Let’s explore your best options for expert care, pain relief, and renewed mobility.
1. Menz Clinic – Orlando, Florida
At the top of our list is Menz Clinic, one of the leading names in regenerative medicine and orthopedic care in Orlando. If you’re searching for a trusted provider for your knee injection, this is where your journey should begin.
Why Menz Clinic Stands Out:
- Specializes in knee injection therapies including PRP, corticosteroids, and gel shots
- Utilizes cutting-edge imaging for precise, pain-free treatments
- Offers non-surgical solutions that target long-term relief
- Known for personalized care tailored to each patient’s lifestyle
Whether you're an athlete or simply someone tired of chronic knee pain, Menz Clinic offers state-of-the-art knee injection options that deliver results.
📍 Location: Orlando, Florida
🌐 Website: www.menzclinic.com
2. Cleveland Clinic – Cleveland, Ohio
The Cleveland Clinic is well-known for its comprehensive approach to joint care. Their team offers some of the most advanced knee injection treatments available in the Midwest.
Services:
- Corticosteroid and hyaluronic acid knee injections
- Advanced diagnostics to identify the root cause of pain
- Specialists in arthritis and sports injuries
They combine precision medicine with a caring, professional environment—ideal for chronic joint pain management.
3. Hospital for Special Surgery (HSS) – New York City, NY
Located in Manhattan, HSS is one of the top orthopedic hospitals in the world. Patients from across the country visit for their renowned knee injection programs.
Key Features:
- Offers PRP and viscosupplementation options
- Highly specialized knee and joint experts
- Patient-first recovery plans
HSS focuses on preserving your joints and extending their function as long as possible—without surgery.
4. Mayo Clinic – Rochester, Minnesota
Mayo Clinic offers a world-class standard of care in orthopedics. Their knee injection procedures are evidence-based and performed by experienced practitioners.
Treatments:
- Cortisone, hyaluronic acid, and PRP knee injections
- Full diagnostic evaluations before treatment
- Emphasis on long-term joint health
Their integrated approach ensures that patients receive the right therapy at the right time.
5. Rush University Medical Center – Chicago, Illinois
Rush offers some of the best orthopedic care in the Midwest. Their knee injection specialists are known for combining modern technology with personalized care plans.
Advantages:
- Image-guided knee injections for pinpoint accuracy
- Great option for patients with osteoarthritis and joint stiffness
- Collaborative team of orthopedic surgeons and rehab experts
Rush aims to get you back to your best life with minimally invasive treatments.
6. Johns Hopkins Orthopaedics – Baltimore, Maryland
Johns Hopkins is more than a name; it's a legacy in quality healthcare. Their orthopedic department excels in both research and practical care, including knee injection treatments.
Highlights:
- PRP, gel, and corticosteroid knee injections
- Treatments customized to lifestyle and severity of pain
- Top-tier imaging and diagnostics
Their methodical approach ensures safer, more effective outcomes for every patient.
7. Kerlan-Jobe Institute – Los Angeles, California
This clinic is a favorite among professional athletes, but you don’t need to be a sports star to benefit from their expertise in knee injection therapy.
Notable Services:
- Cutting-edge PRP and stem cell knee injections
- Sports-specific injury treatment plans
- Rehab services designed for long-term mobility
Whether you're training for a marathon or just want to walk without pain, Kerlan-Jobe delivers world-class care.
8. OrthoCarolina – Charlotte, North Carolina
OrthoCarolina has a strong reputation in the Southeast for orthopedic excellence. They make high-quality knee injection treatments accessible and affordable.
What Makes Them Unique:
- Efficient scheduling and short wait times
- Gel and cortisone knee injections tailored to your needs
- Comprehensive follow-up with physical therapy and wellness planning
Their collaborative care model ensures you're never navigating recovery alone.
9. Texas Orthopedics – Austin, Texas
Serving Central Texas, this clinic is known for its multidisciplinary approach to joint pain. Their knee injection solutions are based on years of clinical success.
Services Offered:
- Cortisone and PRP knee injections
- Same-day diagnostics with onsite radiology
- Experienced doctors who focus on patient education
They take the time to understand your goals and guide you through every step of treatment.
10. Andrews Sports Medicine – Birmingham, Alabama
This clinic is the go-to for high-level athletes, but it’s equally adept at helping everyday individuals find relief through non-surgical options like knee injections.
Benefits:
- PRP and gel-based knee injection therapies
- Custom recovery plans for optimal function
- Collaborative rehab and monitoring
With their focus on performance and mobility, Andrews is ideal for those wanting to stay active well into the future.
What Are Knee Injections and Why Should You Consider Them?
A knee injection involves administering medication directly into the knee joint to reduce inflammation, ease pain, and improve function. It’s an excellent alternative if you’ve tried medications or physical therapy without success.
Most Common Types:
- Corticosteroids – Fast-acting pain and inflammation relief
- Hyaluronic Acid (Gel) – Adds lubrication and cushioning to the joint
- PRP (Platelet-Rich Plasma) – Uses your own blood to regenerate damaged tissue
- Stem Cell Therapy – Encourages healing and tissue regrowth
Is a Knee Injection Right for You?
Consider a knee injection if:
- You experience chronic knee pain or stiffness
- You have osteoarthritis, tendonitis, or bursitis
- Physical therapy hasn't been effective
- You want to delay or avoid knee surgery
These injections are typically quick, minimally painful, and require little to no downtime.
Final Thoughts
Knee pain is more than just an annoyance—it can keep you from enjoying life. The right knee injection can be the turning point toward a healthier, more active lifestyle.
If you're ready to take control of your knee pain, start with the best: Menz Clinic in Orlando. With cutting-edge treatments and a patient-first approach, they’re leading the way in knee injection therapy.
Explore any of the other top clinics on this list and schedule a consultation to get expert advice tailored to your condition. Relief could be just one injection away.