The global upstream bioprocessing market size is expected to reach USD 59.24 billion by 2030, registering a CAGR of 14.3% from 2024 to 2030, according to a new report by Grand View Research, Inc. Commercial success and wide acceptance of biopharmaceuticals have provided lucrative growth avenues to several in house as well as contract manufacturing biopharmaceutical companies. Furthermore, a confluence of factors, such as high demand for biosimilars and biologics, launch of improved cost-effective technologies, and growing acceptance of single-use systems have driven the revenue performance of the market.
Start-ups and new market entrants often face budget constraints while establishing new biomanufacturing plants. Thus, these entities expand their biotherapeutics portfolio by outsourcing the production process to contract services, thereby aiding in revenue growth for upstream bioprocessing services.
Continuous upstream bioprocessing has greatly benefited the bioprocessing industry. Rising implementation of methods, such as acoustic wave technology and continuous centrifugation, for clarification of bioreactor cultures tends to minimize the clarification burden. This, in turn, increases the cell-culture densities, consequently resulting in efficient upstream processes.
Ongoing advancements in cell line productivity with respect to protein expression and clone screening are expected to result in the fastest CAGR of cell culture products over the forecast period. Cell culture is considered as the most challenging and crucial step in upstream bioprocessing, and thus demands more attention with respect to technological intricacies, resulting in the largest share in the upstream bioprocessing market.
Factors such as multi-use systems incur one-time investment, are applicable for larger bioprocessing volumes and maintain the pH and oxygen accurately resulting in high usage rate of these systems. However, a paradigm shift from conventional stainless-steel bioreactors to single-use bioreactor systems has attributed to the lucrative growth of the single-use segment.
Key market players are adopting strategic initiatives, such as novel product developments, mutually beneficial partnerships, agreements, and geographical expansion to reinforce their market presence. For instance, in February 2019, Danaher Corporation signed an agreement to acquire the Biopharma business of GE Life Sciences. The acquisition broadened Danaher’s market presence with the addition of GE Biopharma’s cell culture media, single-use technologies, development instrumentation, and consumables to its existing portfolio.
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Upstream Bioprocessing Market Report Highlights
High availability of bioreactors and continuous launches of single-use bioreactors by the key market players can be attributed to the remarkable revenue share of the bioreactors segment
Presence of well-established biopharmaceutical manufacturing firms capable of performing in-house bioproduction has led to the maximum revenue share of this segment
The outsourced segment is expected to grow at the highest CAGR over the forecast period, owing to increase in investments and expansion of manufacturing capabilities through the integration of single-use systems in the plants by CMOs
North America dominated the market and accounted for a share of 36.2% in 2023 as a result of the continuous innovations in biotechnology and rising preferences for biopharmaceuticals in the region. Moreover, the presence of substantial in-house biopharmaceutical manufacturers coupled with numerous investments in the U.S. biologics market has driven the growth
Asia Pacific is expected to be the fastest-growing region in the market and is expected to grow at a CAGR of 17.4% during the forecast period due to growing awareness about the rapid analytical methods that can be used for in-process control during the upstream workflows
Upstream Bioprocessing Market Segmentation
Grand View Research has segmented the upstream bioprocessing market on the basis of on product, workflow, use type, mode, and region:
Upstream Bioprocessing Product Outlook (Revenue, USD Million, 2018 - 2030)
Bioreactors/Fermenters
Cell Culture Products
Filters
Bioreactors Accessories
Bags & Containers
Others
Upstream Bioprocessing Workflow Outlook (Revenue, USD Million, 2018 - 2030)
Media Preparation
Cell Culture
Cell Separation
Upstream Bioprocessing Use Type Outlook (Revenue, USD Million, 2018 - 2030)
Multi-use
Single-use
Upstream Bioprocessing Mode Outlook (Revenue, USD Million, 2018 - 2030)
In-house
Outsourced
Upstream Bioprocessing Regional Outlook (Revenue, USD Million, 2018 - 2030)
North America
U.S.
Canada
Europe
Germany
UK
France
Italy
Spain
Denmark
Norway
Sweden
Asia Pacific
Japan
China
India
Australia
Thailand
South Korea
Latin America
Brazil
Mexico
Argentina
MEA
South Africa
Saudi Arabia
UAE
Kuwait
List of Key Players in the Upstream Bioprocessing Market
Thermo Fisher Scientific, Inc.
Merck KGaA
Corning Incorporated
Sartorius AG
Eppendorf AG
Danaher
Boehringer Ingelheim GmbH
Applikon Biotechnology
PBS Biotech, Inc.
Lonza
VWR International, LLC
Meissner Filtration Products, Inc.
Repligen Corporation
Entegris
Kuhner AG
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About Grand View Research
Grand View Research, Inc. is a U.S. based market research and consulting company, registered in the State of California and headquartered in San Francisco. The company provides syndicated research reports, customized research reports, and consulting services. To help clients make informed business decisions, we offer market intelligence studies ensuring relevant and fact-based research across a range of industries, from technology to chemicals, materials and healthcare.
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