In Comparison With Sanger Sequencing, Next Generation Sequencing Captures a Broader Spectrum of Mutations

Cancer is a disease of the genome because it is caused by somatically acquired mutations, which is the fundamental tenet of cancer genomics. Despite the fact that capillary-based cancer sequencing has been ongoing for more than ten years, the scope of these studies was limited to a small number of samples and candidate genes. Since the development of Next Generation Sequencing, cancer genomes have been systematically studied in their entirety. Several large-scale cancer genome projects around the world, including a specifically focused paediatric cancer genome project, are currently engaged in this endeavour.

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