bocsci118's articles Asian Rhinoplasty Everything You Need to Know Asian rhinoplasty, also known as Asian nose surgery or Asian nose job, is a cosmetic procedure that focuses on reshaping and enhancing the nose to achieve a more balanced and aesthetically pleasing appearance. In this comprehensive guide, we will explore what Asian rhinoplasty is, what it can achieve, what's included in the procedure, its pros […] January 3, 2024January 3, 2024 Saving Bookmark this article Bookmarked cIAP1 ligand 2 cIAP1 ligand 2 cIAP1 ligand 2 is the LCL161 derivative based IAP ligand. cIAP1 ligand 2 can be connected to the ABL ligand for protein by a linker to form SNIPER. October 24, 2021October 24, 2021 Saving Bookmark this article Bookmarked cIAP1 ligand 1 cIAP1 ligand 1 cIAP1 ligand 1 is the LCL161 derivative based IAP ligand. cIAP1 ligand 1 can be connected to the ABL ligand for protein by a linker to form SNIPER. October 24, 2021October 24, 2021 Saving Bookmark this article Bookmarked Ch55-O-C3-carbaldehyde Ch55-O-C3-carbaldehyde Ch55-O-C3-carbaldehyde (RAR ligand 1) is a Ch 55-based ligand, which targets RAR. Ch55-O-C3-carbaldehyde (RAR ligand 1) binds to cIAP1 ligand Bestatin via a linker to form SNIPER. October 24, 2021October 24, 2021 Saving Bookmark this article Bookmarked c-Di-GMP c-Di-GMP Cyclic diguanosine monophosphate, sodium salt; Cyclic-di-GMP sodium salt October 24, 2021October 24, 2021 Saving Bookmark this article Bookmarked Imidazopyridines Building Blocks Imidazopyridines Building Blocks 6-Methylimidazo[1,2-a]pyridine-2-methanamine Dihydrochloride October 24, 2021October 24, 2021 Saving Bookmark this article Bookmarked Imidazoles Building Blocks Imidazoles Building Blocks alpha-(Trifluoromethyl)-1-methyl-1H-imidazole-2-methanol October 24, 2021October 24, 2021 Saving Bookmark this article Bookmarked Heterocyclic product Heterocyclic product The search for biologically active compounds is the driving force in pharmaceutical synthesis. Since the majority of new molecules entering clinical studies contains at least one heterocyclic moiety predominantly N-heterocyclic ones the modification of these ring systems plays an important role during drug development. October 24, 2021October 24, 2021 Saving Bookmark this article Bookmarked Halides Building Blocks Halides Building Blocks 2-Iodo-4-nitro-1-(trifluoromethoxy)benzene October 24, 2021October 24, 2021 Saving Bookmark this article Bookmarked 2305369-00-8 2305369-00-8 Pomalidomide-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. October 4, 2021October 4, 2021 Saving Bookmark this article Bookmarked 1957235-66-3 1957235-66-3 Pomalidomide-C2-NH2 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 17 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. October 4, 2021October 4, 2021 Saving Bookmark this article Bookmarked 77855-76-6 77855-76-6 PEG6-(CH2CO2H)2 is a symmetric PEG PROTAC linker, for the synthesis of Homo-PROTACs which is bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. October 4, 2021October 4, 2021 Saving Bookmark this article Bookmarked 51951-05-4 51951-05-4 PEG3-O-CH2COOH is a PROTAC linker can be used in the synthesis of a series of SNIPER(ER)s. October 4, 2021October 4, 2021 Saving Bookmark this article Bookmarked 2249750-27-2 2249750-27-2 Nutlin carboxylic acid is the Nutlin 3-based MDM2 ligand. Nutlin carboxylic acid (MDM2 ligand 1) can be connected to the ligand for protein by a linker to form PROTACs. October 4, 2021October 4, 2021 Saving Bookmark this article Bookmarked 1352827-50-9 1352827-50-9 N-Methylated pomalidomide is an E3 ligase ligand used as a negative control of pomalidomide for PROTAC technology. October 4, 2021October 4, 2021 Saving Bookmark this article Bookmarked 189808-70-6 189808-70-6 NH2-PEG3-C1-Boc is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 5 can be used in the synthesis of a series of PROTACs. October 4, 2021October 4, 2021 Saving Bookmark this article Bookmarked 57260-73-8 57260-73-8 NH2-C2-NH-Boc is a PROTAC linker, which refers to the alkyl chain composition. October 4, 2021October 4, 2021 Saving Bookmark this article Bookmarked Cyclohexane product Cyclohexane product 3-(cyclohexylcarbamoyl)prop-2-enoic acid October 4, 2021October 4, 2021 Saving Bookmark this article Bookmarked Cyclobutane Building Blocks Cyclobutane Building Blocks N-(2,4,4-trimethylpentan-2-yl)cyclobutanamine October 4, 2021October 4, 2021 Saving Bookmark this article Bookmarked Carbonyl Building Blocks Carbonyl Building Blocks Ethyl 6-Chloroimidazo[1,2-b]pyridazin-2-ylcarbamate October 4, 2021October 4, 2021 Saving Bookmark this article Bookmarked Carbazoles Building Blocks product Carbazoles Building Blocks product 9-Methyl-2,3,4,9-tetrahydro-1H-carbazole-6-D October 4, 2021October 4, 2021 Saving Bookmark this article Bookmarked Bridged Compounds Building Blocks Bridged Compounds Building Blocks endo-tert-butyl (1R,5S)-6-amino-3-azabicyclo[3.1.1]heptane-3-carboxylate October 4, 2021October 4, 2021 Saving Bookmark this article Bookmarked Boronic Esters product Boronic Esters product 3-Carboxy-5-nitrophenylboronic Acid October 4, 2021October 4, 2021 Saving Bookmark this article Bookmarked Benzoxazole/Benzothiazole Building Blocks product Benzoxazole/Benzothiazole Building Blocks product 2-Aminobenzothiazole-5-carbonitrile October 4, 2021October 4, 2021 Saving Bookmark this article Bookmarked Benzoxazines Building Blocks product Benzoxazines Building Blocks product 8-Chloro-2,2-dimethyl-2H-benzo[b][1,4]oxazin-3(4H)-one October 4, 2021October 4, 2021 Saving Bookmark this article Bookmarked LCL161-O-Me LCL161-O-Me LCL161-O-Me, the LCL161 derivative (IAP ligand) moiety, binds to ABL inhibitor via a linker to form SNIPER. August 31, 2021August 31, 2021 Saving Bookmark this article Bookmarked KB02-SLF KB02-SLF KB02-SLF is a PROTAC-based nuclear FKBP12 degrader (molecular glue). KB02-SLF promotes nuclear FKBP12 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems August 31, 2021August 31, 2021 Saving Bookmark this article Bookmarked KB02-JQ1 KB02-JQ1 KB02-JQ1 is a highly selective and PROTAC-based BRD4 degrader (molecular glue), but does not degrade BRD2 or BRD3. KB02-JQ1 promotes BRD4 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological August 31, 2021August 31, 2021 Saving Bookmark this article Bookmarked JUN68744 JUN68744 JUN68744 is a useful peptide linker for synthesis of PSMA-617 (vipivotide tetraxetan), which is a ligand used to make 177Lu-PSMA-617, a radioactive molecule to fight cancer. August 31, 2021August 31, 2021 Saving Bookmark this article Bookmarked (+)-JQ1 PA (+)-JQ1 PA (+)-JQ1 PA is the BET bromodomain inhibitor (+)-JQ1 used for click target in PROTAC technology. August 31, 2021August 31, 2021 Saving Bookmark this article Bookmarked (+)-JQ1 carboxylic acid (+)-JQ1 carboxylic acid (+)-JQ1 carboxylic acid is the carboxylic acid form of BET bromodomain inhibitor (+)-JQ1. August 31, 2021August 31, 2021 Saving Bookmark this article Bookmarked JH-XI-10-02 JH-XI-10-02 JH-XI-10-02 is a potent and selective degrader of CDK8, with an IC50 of 159 nM, based on PROTAC. JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19. August 31, 2021August 31, 2021 Saving Bookmark this article Bookmarked Indisulam Indisulam Molecular glue; degrades mRNA splicing factor RBM39 August 31, 2021August 31, 2021 Saving Bookmark this article Bookmarked Allenes Building Blocks Allenes Building Blocks Allenes is a class of unsaturated compounds with cumulated double bonds. Featured with the same carbon atom possessing two orthogonal π orbitals, the electron cloud density of allenes can be tuned by substituent effect. August 31, 2021August 31, 2021 Saving Bookmark this article Bookmarked Alkynes Building Blocks Alkynes Building Blocks Amine is a class of organic compound containing at least one N atom. In other words, amine can be regarded as substituted product of ammonia gas in which one or multiple hydrogen atoms are replaced by hydrocarbons August 31, 2021August 31, 2021 Saving Bookmark this article Bookmarked Alkynes product Alkynes product Allenes is a class of unsaturated compounds with cumulated double bonds. Featured with the same carbon atom possessing two orthogonal π orbitals, the electron cloud density of allenes can be tuned by substituent effect. August 31, 2021August 31, 2021 Saving Bookmark this article Bookmarked Alkynes Building Blocks product Alkynes Building Blocks product Alkynes are aliphatic hydrocarbons containing at least one carbon-carbon triple bond with CnH2n-2 stoichiometry. The carbon-carbon triple bond forms two sets of overlapping p orbitals, August 31, 2021August 31, 2021 Saving Bookmark this article Bookmarked Alkenes Building Blocks Alkenes Building Blocks Alkenes, a significant class of unsaturated hydrocarbon, possess a carbon–carbon double bond. They can fall into two broad categories, namely, acyclic alkenes and cyclic alkynes. August 31, 2021August 31, 2021 Saving Bookmark this article Bookmarked butane alkanes or alkenes butane alkanes or alkenes Alkanes August 31, 2021August 31, 2021 Saving Bookmark this article Bookmarked Alcohols product Alcohols product The molecules containing the hydroxyl groups bonded are called alcohols with the general formula CnH2n+1OH. Once the hydroxyl groups are installed on the aromatic rings, they got a new name, August 31, 2021August 31, 2021 Saving Bookmark this article Bookmarked Loading Load more
Asian Rhinoplasty Everything You Need to Know Asian rhinoplasty, also known as Asian nose surgery or Asian nose job, is a cosmetic procedure that focuses on reshaping and enhancing the nose to achieve a more balanced and aesthetically pleasing appearance. In this comprehensive guide, we will explore what Asian rhinoplasty is, what it can achieve, what's included in the procedure, its pros […] January 3, 2024January 3, 2024 Saving Bookmark this article Bookmarked
cIAP1 ligand 2 cIAP1 ligand 2 cIAP1 ligand 2 is the LCL161 derivative based IAP ligand. cIAP1 ligand 2 can be connected to the ABL ligand for protein by a linker to form SNIPER. October 24, 2021October 24, 2021 Saving Bookmark this article Bookmarked
cIAP1 ligand 1 cIAP1 ligand 1 cIAP1 ligand 1 is the LCL161 derivative based IAP ligand. cIAP1 ligand 1 can be connected to the ABL ligand for protein by a linker to form SNIPER. October 24, 2021October 24, 2021 Saving Bookmark this article Bookmarked
Ch55-O-C3-carbaldehyde Ch55-O-C3-carbaldehyde Ch55-O-C3-carbaldehyde (RAR ligand 1) is a Ch 55-based ligand, which targets RAR. Ch55-O-C3-carbaldehyde (RAR ligand 1) binds to cIAP1 ligand Bestatin via a linker to form SNIPER. October 24, 2021October 24, 2021 Saving Bookmark this article Bookmarked
c-Di-GMP c-Di-GMP Cyclic diguanosine monophosphate, sodium salt; Cyclic-di-GMP sodium salt October 24, 2021October 24, 2021 Saving Bookmark this article Bookmarked
Imidazopyridines Building Blocks Imidazopyridines Building Blocks 6-Methylimidazo[1,2-a]pyridine-2-methanamine Dihydrochloride October 24, 2021October 24, 2021 Saving Bookmark this article Bookmarked
Imidazoles Building Blocks Imidazoles Building Blocks alpha-(Trifluoromethyl)-1-methyl-1H-imidazole-2-methanol October 24, 2021October 24, 2021 Saving Bookmark this article Bookmarked
Heterocyclic product Heterocyclic product The search for biologically active compounds is the driving force in pharmaceutical synthesis. Since the majority of new molecules entering clinical studies contains at least one heterocyclic moiety predominantly N-heterocyclic ones the modification of these ring systems plays an important role during drug development. October 24, 2021October 24, 2021 Saving Bookmark this article Bookmarked
Halides Building Blocks Halides Building Blocks 2-Iodo-4-nitro-1-(trifluoromethoxy)benzene October 24, 2021October 24, 2021 Saving Bookmark this article Bookmarked
2305369-00-8 2305369-00-8 Pomalidomide-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. October 4, 2021October 4, 2021 Saving Bookmark this article Bookmarked
1957235-66-3 1957235-66-3 Pomalidomide-C2-NH2 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 17 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. October 4, 2021October 4, 2021 Saving Bookmark this article Bookmarked
77855-76-6 77855-76-6 PEG6-(CH2CO2H)2 is a symmetric PEG PROTAC linker, for the synthesis of Homo-PROTACs which is bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. October 4, 2021October 4, 2021 Saving Bookmark this article Bookmarked
51951-05-4 51951-05-4 PEG3-O-CH2COOH is a PROTAC linker can be used in the synthesis of a series of SNIPER(ER)s. October 4, 2021October 4, 2021 Saving Bookmark this article Bookmarked
2249750-27-2 2249750-27-2 Nutlin carboxylic acid is the Nutlin 3-based MDM2 ligand. Nutlin carboxylic acid (MDM2 ligand 1) can be connected to the ligand for protein by a linker to form PROTACs. October 4, 2021October 4, 2021 Saving Bookmark this article Bookmarked
1352827-50-9 1352827-50-9 N-Methylated pomalidomide is an E3 ligase ligand used as a negative control of pomalidomide for PROTAC technology. October 4, 2021October 4, 2021 Saving Bookmark this article Bookmarked
189808-70-6 189808-70-6 NH2-PEG3-C1-Boc is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 5 can be used in the synthesis of a series of PROTACs. October 4, 2021October 4, 2021 Saving Bookmark this article Bookmarked
57260-73-8 57260-73-8 NH2-C2-NH-Boc is a PROTAC linker, which refers to the alkyl chain composition. October 4, 2021October 4, 2021 Saving Bookmark this article Bookmarked
Cyclohexane product Cyclohexane product 3-(cyclohexylcarbamoyl)prop-2-enoic acid October 4, 2021October 4, 2021 Saving Bookmark this article Bookmarked
Cyclobutane Building Blocks Cyclobutane Building Blocks N-(2,4,4-trimethylpentan-2-yl)cyclobutanamine October 4, 2021October 4, 2021 Saving Bookmark this article Bookmarked
Carbonyl Building Blocks Carbonyl Building Blocks Ethyl 6-Chloroimidazo[1,2-b]pyridazin-2-ylcarbamate October 4, 2021October 4, 2021 Saving Bookmark this article Bookmarked
Carbazoles Building Blocks product Carbazoles Building Blocks product 9-Methyl-2,3,4,9-tetrahydro-1H-carbazole-6-D October 4, 2021October 4, 2021 Saving Bookmark this article Bookmarked
Bridged Compounds Building Blocks Bridged Compounds Building Blocks endo-tert-butyl (1R,5S)-6-amino-3-azabicyclo[3.1.1]heptane-3-carboxylate October 4, 2021October 4, 2021 Saving Bookmark this article Bookmarked
Boronic Esters product Boronic Esters product 3-Carboxy-5-nitrophenylboronic Acid October 4, 2021October 4, 2021 Saving Bookmark this article Bookmarked
Benzoxazole/Benzothiazole Building Blocks product Benzoxazole/Benzothiazole Building Blocks product 2-Aminobenzothiazole-5-carbonitrile October 4, 2021October 4, 2021 Saving Bookmark this article Bookmarked
Benzoxazines Building Blocks product Benzoxazines Building Blocks product 8-Chloro-2,2-dimethyl-2H-benzo[b][1,4]oxazin-3(4H)-one October 4, 2021October 4, 2021 Saving Bookmark this article Bookmarked
LCL161-O-Me LCL161-O-Me LCL161-O-Me, the LCL161 derivative (IAP ligand) moiety, binds to ABL inhibitor via a linker to form SNIPER. August 31, 2021August 31, 2021 Saving Bookmark this article Bookmarked
KB02-SLF KB02-SLF KB02-SLF is a PROTAC-based nuclear FKBP12 degrader (molecular glue). KB02-SLF promotes nuclear FKBP12 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems August 31, 2021August 31, 2021 Saving Bookmark this article Bookmarked
KB02-JQ1 KB02-JQ1 KB02-JQ1 is a highly selective and PROTAC-based BRD4 degrader (molecular glue), but does not degrade BRD2 or BRD3. KB02-JQ1 promotes BRD4 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological August 31, 2021August 31, 2021 Saving Bookmark this article Bookmarked
JUN68744 JUN68744 JUN68744 is a useful peptide linker for synthesis of PSMA-617 (vipivotide tetraxetan), which is a ligand used to make 177Lu-PSMA-617, a radioactive molecule to fight cancer. August 31, 2021August 31, 2021 Saving Bookmark this article Bookmarked
(+)-JQ1 PA (+)-JQ1 PA (+)-JQ1 PA is the BET bromodomain inhibitor (+)-JQ1 used for click target in PROTAC technology. August 31, 2021August 31, 2021 Saving Bookmark this article Bookmarked
(+)-JQ1 carboxylic acid (+)-JQ1 carboxylic acid (+)-JQ1 carboxylic acid is the carboxylic acid form of BET bromodomain inhibitor (+)-JQ1. August 31, 2021August 31, 2021 Saving Bookmark this article Bookmarked
JH-XI-10-02 JH-XI-10-02 JH-XI-10-02 is a potent and selective degrader of CDK8, with an IC50 of 159 nM, based on PROTAC. JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19. August 31, 2021August 31, 2021 Saving Bookmark this article Bookmarked
Indisulam Indisulam Molecular glue; degrades mRNA splicing factor RBM39 August 31, 2021August 31, 2021 Saving Bookmark this article Bookmarked
Allenes Building Blocks Allenes Building Blocks Allenes is a class of unsaturated compounds with cumulated double bonds. Featured with the same carbon atom possessing two orthogonal π orbitals, the electron cloud density of allenes can be tuned by substituent effect. August 31, 2021August 31, 2021 Saving Bookmark this article Bookmarked
Alkynes Building Blocks Alkynes Building Blocks Amine is a class of organic compound containing at least one N atom. In other words, amine can be regarded as substituted product of ammonia gas in which one or multiple hydrogen atoms are replaced by hydrocarbons August 31, 2021August 31, 2021 Saving Bookmark this article Bookmarked
Alkynes product Alkynes product Allenes is a class of unsaturated compounds with cumulated double bonds. Featured with the same carbon atom possessing two orthogonal π orbitals, the electron cloud density of allenes can be tuned by substituent effect. August 31, 2021August 31, 2021 Saving Bookmark this article Bookmarked
Alkynes Building Blocks product Alkynes Building Blocks product Alkynes are aliphatic hydrocarbons containing at least one carbon-carbon triple bond with CnH2n-2 stoichiometry. The carbon-carbon triple bond forms two sets of overlapping p orbitals, August 31, 2021August 31, 2021 Saving Bookmark this article Bookmarked
Alkenes Building Blocks Alkenes Building Blocks Alkenes, a significant class of unsaturated hydrocarbon, possess a carbon–carbon double bond. They can fall into two broad categories, namely, acyclic alkenes and cyclic alkynes. August 31, 2021August 31, 2021 Saving Bookmark this article Bookmarked
butane alkanes or alkenes butane alkanes or alkenes Alkanes August 31, 2021August 31, 2021 Saving Bookmark this article Bookmarked
Alcohols product Alcohols product The molecules containing the hydroxyl groups bonded are called alcohols with the general formula CnH2n+1OH. Once the hydroxyl groups are installed on the aromatic rings, they got a new name, August 31, 2021August 31, 2021 Saving Bookmark this article Bookmarked
