Tramadol is a unique compound with both a moderate mu-opioid effect and a moderate monoaminergic effect. Tramadol has a more acceptable side-effect profile in comparison with tricyclic antidepressants and antiepileptics. Although possible, tolerance and dependence pose uncommon complications of the treatment. Out of the four main pain types, the action of Tramadol is not limited to neuropathic pain only but also includes suppression of noxious pains.
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