Velpanat is a fixed-dose combination antiviral medication used for the treatment of chronic Hepatitis C virus (HCV) infection, covering all six major genotypes (1-6). Each tablet contains Sofosbuvir 400 mg and Velpatasvir 100 mg, making it a convenient, once-daily oral treatment that offers a high cure rate across diverse patient populations.
Velpanat is a breakthrough, pangenotypic, direct-acting antiviral (DAA) medication developed by Natco Pharma for the treatment of chronic Hepatitis C infection in adults. It contains two potent antiviral agents:
- Sofosbuvir (400 mg) – an NS5B polymerase inhibitor
- Velpatasvir (100 mg) – an NS5A inhibitor
Together, these drugs work synergistically to stop the hepatitis C virus from replicating and spreading in the body. Velpanat is especially effective because it can treat all genotypes of HCV (1 through 6), reducing the need for genotype-specific regimens.
Velpanat is typically administered once daily for 12 weeks, with or without Ribavirin based on the patient’s liver condition (e.g., decompensated cirrhosis).
Key Features:
- Contains Sofosbuvir 400 mg + Velpatasvir 100 mg
- Pangenotypic – treats genotypes 1 to 6 of HCV
- High cure rates (SVR >95%) after a 12-week treatment course
- No need for interferon or multiple pills
- Manufactured by Natco Pharma Ltd, a trusted name in Hepatitis C treatment
- WHO-prequalified and widely used in global treatment programs
Indications:
- Chronic Hepatitis C infection (genotypes 1–6)
- With or without compensated or decompensated cirrhosis
- Suitable for treatment-naïve or treatment-experienced adults
Dosage and Administration:
- Standard dose: One tablet once daily, with or without food
- Treatment duration: Typically 12 weeks; may be 24 weeks in patients with decompensated cirrhosis (often with Ribavirin)
- Follow your doctor’s complete instructions for optimal results
Precautions:
- Not recommended during pregnancy (especially if combined with Ribavirin)
- Use with caution in patients with severe liver or kidney disease
- May interact with other medications, especially antacids, anticonvulsants, and HIV drugs
- Inform your doctor of any pre-existing conditions, including co-infection with HIV or Hepatitis B
Storage Instructions:
- Store at room temperature below 30°C
- Keep away from moisture, heat, and direct sunlight
- Keep out of reach of children
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