Amit Sharma's articles Sirolimus Medical uses Sirolimus, also can be addressed as rapamycin. In the month of September 1999, rapamycin got the approval by the US FDA (Food and Drug Administration). It is marketed under the brand name Rapamune by Pfizer (formerly by Wyeth). Sirolimus specifically is a macrolide compound that is introduced to coat coronary stents, prevent organ transplant rejection […] July 1, 2021July 1, 2021 Saving Bookmark this article Bookmarked What is the medical use of sorafenib Sorafenib is used in the treatment of: Hepatocellular Carcinoma Renal Cell Carcinoma Thyroid cancer More info:- On December 20, 2005, the Food and Drug Administration approved sorafenib for the treatment of patients with advanced renal cell carcinoma. On November 19, 2007, the Food and Drug Administration approved sorafenib for the treatment of patients with unresectable […] July 1, 2021July 1, 2021 Saving Bookmark this article Bookmarked Afatinib in Late Stage EGFR-Mutant NSCLC According to final outcomes of the ASCENT trial, which was came out during the International Association for the Study of Lung Cancer 2021 Targeted Therapies of Lung Cancer Meeting, “Integrating afatinib (Gilotrif) into standard-of-care chemoradiation either with or without surgery showed the encouraging efficacy, feasibility, and safety outcomes in patients with stage-III EGFR mutation +Ve […] June 24, 2021June 24, 2021 Saving Bookmark this article Bookmarked Carmustin Injection- Medical uses Carmustine specifically belongs to a group of anticancer drugs known as nitrosourea that are believed to act in order to slow the growth of cancerous cells. The carmustine injection is effective in the following malignant neoplasms as a single agent or along with other antineoplastic agents or other therapeutic measures (radiotherapy, surgery): Brain tumours (glioblastoma, […] June 24, 2021June 24, 2021 Saving Bookmark this article Bookmarked Palbociclib- Medical uses Palbociclib specifically is an orally existing CDK inhibitor with antineoplastic activity. It has potential and selectively inhibits the CDK4 and CDK6, thereby inhibiting the Rb protein phosphorylation early in the G1 phase leading to the cell cycle arrest. This helps suppress the DNA replication as well as reduces the tumor cell proliferation. CDK4 and CDK6 […] June 24, 2021June 24, 2021 Saving Bookmark this article Bookmarked What are the medical uses of Abemaciclib Abemaciclib specifically is the third small molecule orally bioavailable inhibitor of CDK4 and CDK6. This agent is structurally different to ribociclib and palbociclib, in that it exhibits a greater selectivity for the CDK4 in vitro. One group fortunately showed the ability of the abemaciclib in order to exert the CDK4/6 inhibition and subsequent cell arrest […] May 25, 2021May 25, 2021 Saving Bookmark this article Bookmarked History of Nintedanib Nintedanib falls under the small molecule tyrosine-kinase inhibitor, targeting vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. On 15'th October 2014, US Food and Drug Administration granted the approval to this small molecule tyrosine-kinase inhibitor in order to treat idiopathic pulmonary fibrosis, and got a positive perspective from […] May 25, 2021May 25, 2021 Saving Bookmark this article Bookmarked History of Anastrozole Anastrozole (Arimidex) specifically falls under the aromatase inhibiting family of medicines, which acts in order to block the production of estrogens in the body. It has antiestrogenic effects. It is prescribed in addition to other treatments for the treatment of breast cancer. Specifically, anastrozole 1 mg is recommended for treating the hormone receptor +Ve breast […] May 13, 2021May 13, 2021 Saving Bookmark this article Bookmarked History of Sofosbuvir Sofosbuvir (Sovaldi) falls under the nucleotide analog family of medication, which works in order to block the hepatitis C NS5B protein. In the year of 2007, Sofosbuvir was originated by Michael Sofia, a scientist at Pharmasset, and in the year of 2010, it was first tested in people. In the year of 2011 Gilead Sciences […] May 13, 2021May 13, 2021 Saving Bookmark this article Bookmarked History of Bosutinib Bosutinib (Bosulif) is a kind of small molecule BCR-ABL and src TKI (Tyrosine Kinase Inhibitor), originally synthesized by Wyeth, and is being developed by Pfizer. Bosutinib specifically originated in order to treat adult patients with chronic, accelerated, or blast phase Ph+ CML (Chronic Myelogenous Leukemia). In the month of January, 2012, Pfizer announced FDA acceptance […] May 3, 2021May 3, 2021 Saving Bookmark this article Bookmarked History of Abiraterone Abiraterone acetate (Zytiga) falls under anti androgens (anti-testosterone), which is used in order to treat prostate cancer. Specifically it is recommended along with a corticosteroid for the metastatic castration resistant prostate cancer (mCRPC) and metastatic high risk castration sensitive prostate cancer (mCSPC). In the month December, 2010, Centocor Ortho Biotech Inc. announced the NDA submission […] April 29, 2021April 29, 2021 Saving Bookmark this article Bookmarked History of Ribociclib Ribociclib (Kisqali) falls under the inhibitor of cyclin D1/CDK4 and CDK6, and originated in order to treat certain sorts of breast cancer. This inhibitor is also being investigated in the form of treatment for certain other drug resistant cancers. Ribociclib was developed by Astex Pharma and Novartis. In the month of March, 2017, the Food […] April 27, 2021April 27, 2021 Saving Bookmark this article Bookmarked History of Tofacitinib Tofacitinib (xeljanz) falls under the janus kinase (JAK) inhibitors, discovered and developed by the National Institutes of Health and Pfizer. It is a kind of small molecule, rather than a biologic. The potential significance of JAK3 inhibitor was foremost originated in the laboratory of John O'Shea, an immunologist at the National Institute of Arthritis and […] April 27, 2021April 27, 2021 Saving Bookmark this article Bookmarked History of Apremilast In the year of 2014, Apremilast was approved by the US FDA in order to treat adult patients with the active psoriatic arthritis and moderate to severe plaque psoriasis. In the year of 2019, Apremilast was approved in order to treat oral ulcers associated with Behçet's disease. Technically named a novel PDE4 inhibitor, apremilast (otezla) […] April 23, 2021April 23, 2021 Saving Bookmark this article Bookmarked Important note for those patient who are on Carfilzomib Patients should be counseled to avoid dehydration, since patients receiving carfilzomib therapy may feel vomiting or diarrhea. Advise patients to seek medical assistance in case they have symptoms of dehydration. Patients should be advised that they may have cough/shortness of breath (dyspnea) while carfilzomib injection treatment. Cough or shortness of breath most commonly occurs within […] March 25, 2021March 25, 2021 Saving Bookmark this article Bookmarked Sorafenib: A Multikinase Inhibitor Important:- This post is originally published here. Sorafenib (Brand name Nexavar) is prescribed for the treatment of liver cancer (hepatocellular carcinoma) which cannot be eliminated through surgery. Sorafenib is prescribed for the treatment of kidney cancer (locally advanced/metastatic renal cell carcinoma) in adult patients who failed/intolerant to prior systemic therapy. It is not known whether […] March 22, 2021March 22, 2021 Saving Bookmark this article Bookmarked
Sirolimus Medical uses Sirolimus, also can be addressed as rapamycin. In the month of September 1999, rapamycin got the approval by the US FDA (Food and Drug Administration). It is marketed under the brand name Rapamune by Pfizer (formerly by Wyeth). Sirolimus specifically is a macrolide compound that is introduced to coat coronary stents, prevent organ transplant rejection […] July 1, 2021July 1, 2021 Saving Bookmark this article Bookmarked
What is the medical use of sorafenib Sorafenib is used in the treatment of: Hepatocellular Carcinoma Renal Cell Carcinoma Thyroid cancer More info:- On December 20, 2005, the Food and Drug Administration approved sorafenib for the treatment of patients with advanced renal cell carcinoma. On November 19, 2007, the Food and Drug Administration approved sorafenib for the treatment of patients with unresectable […] July 1, 2021July 1, 2021 Saving Bookmark this article Bookmarked
Afatinib in Late Stage EGFR-Mutant NSCLC According to final outcomes of the ASCENT trial, which was came out during the International Association for the Study of Lung Cancer 2021 Targeted Therapies of Lung Cancer Meeting, “Integrating afatinib (Gilotrif) into standard-of-care chemoradiation either with or without surgery showed the encouraging efficacy, feasibility, and safety outcomes in patients with stage-III EGFR mutation +Ve […] June 24, 2021June 24, 2021 Saving Bookmark this article Bookmarked
Carmustin Injection- Medical uses Carmustine specifically belongs to a group of anticancer drugs known as nitrosourea that are believed to act in order to slow the growth of cancerous cells. The carmustine injection is effective in the following malignant neoplasms as a single agent or along with other antineoplastic agents or other therapeutic measures (radiotherapy, surgery): Brain tumours (glioblastoma, […] June 24, 2021June 24, 2021 Saving Bookmark this article Bookmarked
Palbociclib- Medical uses Palbociclib specifically is an orally existing CDK inhibitor with antineoplastic activity. It has potential and selectively inhibits the CDK4 and CDK6, thereby inhibiting the Rb protein phosphorylation early in the G1 phase leading to the cell cycle arrest. This helps suppress the DNA replication as well as reduces the tumor cell proliferation. CDK4 and CDK6 […] June 24, 2021June 24, 2021 Saving Bookmark this article Bookmarked
What are the medical uses of Abemaciclib Abemaciclib specifically is the third small molecule orally bioavailable inhibitor of CDK4 and CDK6. This agent is structurally different to ribociclib and palbociclib, in that it exhibits a greater selectivity for the CDK4 in vitro. One group fortunately showed the ability of the abemaciclib in order to exert the CDK4/6 inhibition and subsequent cell arrest […] May 25, 2021May 25, 2021 Saving Bookmark this article Bookmarked
History of Nintedanib Nintedanib falls under the small molecule tyrosine-kinase inhibitor, targeting vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. On 15'th October 2014, US Food and Drug Administration granted the approval to this small molecule tyrosine-kinase inhibitor in order to treat idiopathic pulmonary fibrosis, and got a positive perspective from […] May 25, 2021May 25, 2021 Saving Bookmark this article Bookmarked
History of Anastrozole Anastrozole (Arimidex) specifically falls under the aromatase inhibiting family of medicines, which acts in order to block the production of estrogens in the body. It has antiestrogenic effects. It is prescribed in addition to other treatments for the treatment of breast cancer. Specifically, anastrozole 1 mg is recommended for treating the hormone receptor +Ve breast […] May 13, 2021May 13, 2021 Saving Bookmark this article Bookmarked
History of Sofosbuvir Sofosbuvir (Sovaldi) falls under the nucleotide analog family of medication, which works in order to block the hepatitis C NS5B protein. In the year of 2007, Sofosbuvir was originated by Michael Sofia, a scientist at Pharmasset, and in the year of 2010, it was first tested in people. In the year of 2011 Gilead Sciences […] May 13, 2021May 13, 2021 Saving Bookmark this article Bookmarked
History of Bosutinib Bosutinib (Bosulif) is a kind of small molecule BCR-ABL and src TKI (Tyrosine Kinase Inhibitor), originally synthesized by Wyeth, and is being developed by Pfizer. Bosutinib specifically originated in order to treat adult patients with chronic, accelerated, or blast phase Ph+ CML (Chronic Myelogenous Leukemia). In the month of January, 2012, Pfizer announced FDA acceptance […] May 3, 2021May 3, 2021 Saving Bookmark this article Bookmarked
History of Abiraterone Abiraterone acetate (Zytiga) falls under anti androgens (anti-testosterone), which is used in order to treat prostate cancer. Specifically it is recommended along with a corticosteroid for the metastatic castration resistant prostate cancer (mCRPC) and metastatic high risk castration sensitive prostate cancer (mCSPC). In the month December, 2010, Centocor Ortho Biotech Inc. announced the NDA submission […] April 29, 2021April 29, 2021 Saving Bookmark this article Bookmarked
History of Ribociclib Ribociclib (Kisqali) falls under the inhibitor of cyclin D1/CDK4 and CDK6, and originated in order to treat certain sorts of breast cancer. This inhibitor is also being investigated in the form of treatment for certain other drug resistant cancers. Ribociclib was developed by Astex Pharma and Novartis. In the month of March, 2017, the Food […] April 27, 2021April 27, 2021 Saving Bookmark this article Bookmarked
History of Tofacitinib Tofacitinib (xeljanz) falls under the janus kinase (JAK) inhibitors, discovered and developed by the National Institutes of Health and Pfizer. It is a kind of small molecule, rather than a biologic. The potential significance of JAK3 inhibitor was foremost originated in the laboratory of John O'Shea, an immunologist at the National Institute of Arthritis and […] April 27, 2021April 27, 2021 Saving Bookmark this article Bookmarked
History of Apremilast In the year of 2014, Apremilast was approved by the US FDA in order to treat adult patients with the active psoriatic arthritis and moderate to severe plaque psoriasis. In the year of 2019, Apremilast was approved in order to treat oral ulcers associated with Behçet's disease. Technically named a novel PDE4 inhibitor, apremilast (otezla) […] April 23, 2021April 23, 2021 Saving Bookmark this article Bookmarked
Important note for those patient who are on Carfilzomib Patients should be counseled to avoid dehydration, since patients receiving carfilzomib therapy may feel vomiting or diarrhea. Advise patients to seek medical assistance in case they have symptoms of dehydration. Patients should be advised that they may have cough/shortness of breath (dyspnea) while carfilzomib injection treatment. Cough or shortness of breath most commonly occurs within […] March 25, 2021March 25, 2021 Saving Bookmark this article Bookmarked
Sorafenib: A Multikinase Inhibitor Important:- This post is originally published here. Sorafenib (Brand name Nexavar) is prescribed for the treatment of liver cancer (hepatocellular carcinoma) which cannot be eliminated through surgery. Sorafenib is prescribed for the treatment of kidney cancer (locally advanced/metastatic renal cell carcinoma) in adult patients who failed/intolerant to prior systemic therapy. It is not known whether […] March 22, 2021March 22, 2021 Saving Bookmark this article Bookmarked
