Catalog No.GC40877

Catalog No.GC40877



Heclin is an inhibitor of HECT E3 ubiquitin ligases (IC50s = 6.8, 6.3, and 6.9 μM for Smurf2, Nedd4, and WWP1 HECT ligase domains, respectively).



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Product has been cited by 2 publications

Adv Sci (2024)：2400560.PMID:38874331Autophagy (2024).PMID:38566321

Description Chemical Properties Product Documents Related Products

Description

Heclin is an inhibitor of HECT E3 ubiquitin ligases (IC50s = 6.8, 6.3, and 6.9 μM for Smurf2, Nedd4, and WWP1 HECT ligase domains, respectively). Heclin inhibits autoubiquitination of Smurf2 in HEK293 cells expressing the human enzyme (IC50 = 9 μM) and reduces ubiquitination of Dishevelled 2 in HEK293 cells expressing Smurf2, Nedd4, or WWP2. Heclin is cytotoxic to HEK293 cells (IC50 = 45 μM).



Chemical Properties

Cas No. 890605-54-6 SDF

Canonical SMILES CC(C1=CC=C(NC(/C=C/C2=CC=C(CC)O2)=O)C=C1)=O

Formula C17H17NO3 M.Wt 283.3

Solubility DMSO: 20 mg/mL,Ethanol: 10 mg/mL Storage Store at -20°C

General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.

To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.

Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.