MEGA-8 2026

(Synonyms: N-octanoyl-N-Methylglucamine)

Catalog No.GC44152

MEGA8 is a nonionic glucoside surfactant obtained by condensation of octanoyl (C8 straight-chain acyl) group with N-methylglucamine.

Products are for research use only. Not for human use. We do not sell to patients.

Size Price Stock Qty

1g

$105.00

In stock

0

5g

$368.00

In stock

0

10g

$683.00

In stock

0

25g

$1,575.00

In stock

0

Description

MEGA-8 is a nonionic glucoside surfactant obtained by condensation of octanoyl (C8 straight-chain acyl) group with N-methylglucamine[1]. MEGA-8 is characterized by its mildness and non-denaturing nature, with a critical micelle concentration (CMC) that is virtually unaffected by temperature in the range of 5–40 °C, and its CMC is 70 mM in salt-free conditions and 5–64 mM under high- and low-salt conditions[2][3]. MEGA-8 is usually used in the preparation of biomaterials or organic compounds and is commonly found in life science research, such as protein extraction and membrane protein solubilization[4][5]. When combined with CHAPS, MEGA-8 synergistically reduces the CMC and enhances surface activity, thereby efficiently solubilizing membrane proteins under mild conditions[6]. MEGA-8 gently displaces PrBP/δ and inhibits the basal activity of PDE6 while maintaining the integrity and homogeneity of the holoenzyme complex, thus providing an ideal detergent environment for the purification and structural studies of retinal phosphodiesterase 6[7].

References:

[1] Jeffrey GA, Maluszynska H. The structures of 1-deoxy-(N-methyloctanamido)-D-glucitol (MEGA-8) and 1-deoxy-(N-methylundecanamido)-D-glucitol (MEGA-11). Acta Crystallogr B. 1989;45 ( Pt 4):447-452.

[2] Walter A, Suchy SE, Vinson PK. Solubility properties of the alkylmethylglucamide surfactants. Biochim Biophys Acta. 1990;1029(1):67-74.

[3] Miyagishi S, Okada K, Asakawa T. Salt Effect on Critical Micelle Concentrations of Nonionic Surfactants, N-Acyl-N-methylglucamides (MEGA-n). J Colloid Interface Sci. 2001;238(1):91-95.

[4] Luescher IF, Unanue ER. Purification and photoaffinity labeling of the I-Ak histocompatibility molecule. J Immunol Methods. 1990;135(1-2):233-245.

[5] Banerjee P, Joo JB, Buse JT, Dawson G. Differential solubilization of lipids along with membrane proteins by different classes of detergents. Chem Phys Lipids. 1995;77(1):65-78.

[6] Ko JS, Oh SW, Kim KW, Nakashima N, Nagadome S, Sugihara G. Blending effects on adsorption and micellization of different membrane protein solubilizers: a thermodynamic study on three mixed systems of CHAPS with MEGA-8, -9 and -10 in pH 7.2 phosphate buffer solution. Colloids Surf B Biointerfaces. 2005;45(2):90-103.

[7] Baker BY, Palczewski K. Detergents stabilize the conformation of phosphodiesterase 6. Biochemistry. 2011;50(44):9520-9531.