bocsciences

bocsciences's articles

  1. Biotech

Effects of Endocytosis on the Receptor Targeting Mechanism of ADC Drugs

ADC is a complex that conjugates cytotoxic small molecule drugs to monoclonal antibodies through a rationally constructed linker, which can selectively deliver effective cytotoxic drugs into tumors. Currently, the FDA has approved 11 ADC drugs for marketing, and hundreds more are in clinical trials.   No. ADC Drugs Targets 1 Trastuzumab emtansine (T-DMI) HER2 2 […]
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  1. Biotech

Precision Fermentation for the Alternative Protein Industry

What is Precision Fermentation   Precision fermentation is a technology that utilizes microorganisms as cell factories to produce specific functional components. It allows microorganisms to be programmed to afford complex organic molecules, such as proteins, enzymes, fats, vitamins, natural pigments, etc. In biology, fermentations refer to specific metabolic pathways that extract energy from molecules, usually in the absence […]
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  1. Biotech

Peptides for Diabetes Research—a Special Offer of BOC Sciences

  BOC Sciences has been constantly enriching its peptide product library for years. Its peptides for diabetes research are recently brought into focus due to the growing concerns on this problem.   According to data from the WHO, a large number of adults are having diabetes mellitus, a chronic metabolic disorder characterized by hyperglycemia. The absolute […]
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  1. Biotech

Stable and Quality Supply of Phosphoramidites Is a Reality at BOC Sciences

As an expert in chemistry, BOC Sciences understands how important the quality of phosphoramidite is to successful oligo synthesis and remarkably, it has taken concrete actions to manufacture certified products.   Hundreds of phosphoramidites for oligonucleotide synthesis, not only the common DNA and RNA phosphoramidites but also 2′-modified phosphoramidites, reverse phosphoramidites, 3′-NH phosphoramidites, etc., are now within the range of BOC […]
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  1. Biotech

BOC Sciences Shares Its Strategic Emphasis on NTPs during the Pandemic

“Whether your studies involve DNA sequencing, cDNA synthesis, RT-PCR, RCA, MDA, DNA labeling, in vitro transcription, siRNA synthesis, or RNA amplification, we stock hundreds of modified or natural NTPs to suit your various molecular biological applications,” a BOC Sciences manager announces to the public.   As an active participant in the biotech and pharmaceutical industry, BOC Sciences emphasizes its […]
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  1. Biotech

Application review of pseudoUridine and its derivatives

Pseudouridine is the most abundant RNA modification in cellular RNA. Pseudouridine (abbreviated by the Greek letter psi- Ψ) is an isomer of the nucleoside uridine in which the uracil is attached via a carbon-carbon instead of a nitrogen-carbon glycosidic bond. The C-C bond gives it more rotational freedom and conformational flexibility. It has an additional […]
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  1. Biotech

mRNA Vaccines and PseudoUridine

1. AbstractThe field of mRNA vaccines has rapidly developed during the pandemic. In order to reduce the immunogenicity of mRNA vaccines, the introduction of naturally modified nucleotides was used. PseudoUridine is the most abundant modified nucleoside in RNA, also known as the “fifth nucleoside.” The introduction of pseudoUridine or N1-methylpseudoUridine into mRNA can effectively reduce […]
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  1. Science / Technology

Vital Solutions to Support COVID-19 Research

Many research institutes and pharmaceutical companies are now actively engaged in COVID-19 research and treatment development, which makes some supportive reagents, services, and consultations in high demand around the world.   This article briefly summarizes several relatively important solutions that can greatly facilitate COVID-19 research.   COVID-19 mRNA Vaccine Development Support The global outbreak of […]
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  1. Science / Technology

Key Elements for Efficient Fermentation Process Optimization in Pharmaceutical Industry

For large- or small-scale fermentation, process optimization in some critical steps plays an important role in improving efficiency because it can directly affect the formation, concentration, and yield of a particular fermentation end product, thus affecting the overall economics.   However, the improvement of fermentation process is frequently associated with a lot of challenges: it's expensive, laborious, open-ended, and time-consuming. There […]
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  1. Science / Technology

An Overview of PseudoUridine Modification in RNAs

It is an efficient way to regulate molecular function by applying specific chemical modifications on biological molecules. This article highlights the current heated pseudoUridine modification in RNA, which suggests new possibilities for novel drug or vaccine discovery.   An Introduction to PseudoUridines PseudoUridine (Ψ) is a post-transcriptional RNA modification that alters RNA-RNA and RNA-protein interactions and affects gene expression. PseudoUridine modification is also […]
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  1. Science / Technology

An Overview of Mainstream Carbohydrates in the Market

As one of the primary biomolecules in nature, carbohydrates are critical elements in nutrition provision, energy transportation, cell composition, etc. In view of their universality and essentiality in research, this article is an exploration of carbohydrates, especially those hot ones in the market.   Chemical Classifications of Carbohydrates There are different ways to classify carbohydrates, such as by formulae or by structures. And the […]
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  1. Biotech

Innovative Impurity Isolation and Identification Techniques at BOC Sciences to Address Pharmaceutical Impurity Issues

New York, United States—June 30, 2022—BOC Sciences announced impurity isolation and identification services using traditional and innovative impurity techniques.   “We’re happy to have achieved consensus with global pharmaceuticals to deal with the NDMA risk and other impurity concerns. We will continue to provide full support taking advantage of our rich experience and expertise,” stated the […]
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  1. Science / Technology

How to Optimize Fermentation Process? Learn from the Workflows of BOC Sciences

From the early stage of strain cultivation to final commercial production, the fermentation production process will go through a complicated set of workflows that require constant optimization. BOC Sciences, working with a group of versatile experts in microbiology, chemistry, and biology, has accumulated much experience in this field.   BOC Sciences divides the whole fermentation […]
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  1. Science / Technology

A Brief Guide to Identify a Reliable Supplier of Phosphoramidites

Synthetic DNA/RNA is an important technique in therapeutic DNA/RNA research, which is the undisputed truth in the pharma industry. However, if you interview a certain number of researchers specializing in DNA/RNA related fields, they would give the feedback that looking for the desired DNA/RNA synthesis materials and identifying a supplier worthy of long-term cooperation would […]
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  1. Science / Technology

A New Phase of BOC Sciences Partnership Expansion Unlocked after TIDES USA 2022

As the grand hybrid event TIDES USA 2022 is drawing to a close, BOC Sciences is reviewing its gains there, particularly many instructive thoughts and comments collected from global researchers. The in-person event TIDES USA 2022: Oligonucleotide & Peptide Therapeutics Conference was successfully concluded on May 12th, while the digital session is still ongoing. BOC Sciences dispatched […]
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  1. Biotech

Antibody-drug Conjugates Manufacturing and Future Focus

Antibody-drug conjugates (ADCs) are formed by covalent biochemical conjugation of monoclonal antibodies (mAb) with payload drugs through small molecular linkers. They are regarded as an emerging class of drugs designed for high-specificity targeting and destruction of cancer cells, since the specificity of mAb to tumor cells allows small-molecule drugs to target tumor tissues, effectively reducing […]
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  1. Biotech

Peptides Labeling with Stable Isotope

Peptides are organic compounds formed by the dehydration of amino acids and intermediate products of protein hydrolysis. Peptides have strong biological activity, which can regulate the functional activities of cells in living organisms, and play a variety of roles in medicine, cosmetics, food, and other fields. With the more and more extensive and in-depth applications […]
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  1. Biotech

BOC Sciences: A Robust Isotope Labeling Service Vendor

New York, United States—May 10, 2022—BOC Sciences is a robust supplier of stable isotope-labeled compounds in the United States. While realizing isotopic labeling with different molecules could be tricky sometimes, the company provides professional stable isotope labeling services for worldwide partners to support them from preclinical to commercial stages.   Stable isotope labeling involves the […]
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  1. Biotech

Complete Virtual Screening Solutions at BOC Sciences to Unleash Novel Drug Discovery Potential

New York, United States—May 17, 2022— Today, BOC Sciences released a complete set of virtual screening solutions to help partners maximize the diversity of hits using its ultra-large-scale purchasable compound libraries. As a robust method to identify promising drug candidates, virtual screening services provided by BOC Sciences not only minimize required experimental screening compounds but […]
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  1. Biotech

BOC Sciences Unveils Access to Comprehensive Set of PROTAC In Vitro Evaluation Services

New York, United States—May 27, 2022—BOC Sciences, a leading life science research and development company, today unveiled access to its full-scale PROTAC in vitro assessment services for biopharmaceutical clients and partners to expedite their PROTAC development from preclinical studies to clinical trials. With this advanced PROTAC development platform, BOC Sciences keeps solidifying its presence in […]
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  1. Biotech

Benefits of Stable Isotope Labelling in Biochemistry Research

Stable isotopes are a type of isotope whose radioactivity cannot be detected by naturally occurring techniques. In nature, the chemical and biological properties of stable isotopes compounds and the corresponding elements compounds are identical except for the mass number. Examples of stable isotopes mainly encompass deuterium, nitrogen-15, oxygen-18, and carbon-13. And stable isotope-labeled compounds are […]
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  1. Biotech

BOC Sciences Unveils Comprehensive Custom Synthesis Services

BOC Sciences unveils its comprehensive custom synthesis services for worldwide partners engaged in biopharmaceutical, chemical, and life science research. With the advanced computer-aided technology and experienced technical team, BOC Sciences offers quality-guaranteed compounds and professional technical support during the whole process.   As an integral part of drug discovery or other chemical industries, chemical synthesis […]
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  1. Biotech

BOC Sciences Announces Featured PROTAC Design Services to Meet New Drug Discovery Goals

BOC Sciences is a comprehensive preclinic-stage pharmaceutical company pioneering drug discovery and research. After years of commitment in this field, BOC Sciences announced today that they can provide concrete and productive PROTAC design services to global customers to meet new drug discovery goals. With a comprehensive and advanced platform, their services range from ligand design and synthesis […]
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  1. Biotech

ADC Technology: A Premier Institution of Antibody-Drug Conjugates Development

ADC Technology, one of the major departments at BOC Sciences, released today a wide range of one-stop services related to antibody-drug conjugates (ADC) development such as antibody selection/modification, ADC payload and linker development, ADC conjugation, and ADC characterization and preclinical evaluation. ADC Technology possesses GMP-grade and ISO-certified contract manufacturing facilities and exploits a custom development […]
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  1. Biotech

PROTAC-based Methods as Traditional PROTAC Protein Degradation Technology Alternatives

In recent years, the transition from inhibition of aberrant protein function to specific degradation of desired proteins with Proteolysis Targeting Chimeras (PROTACs) has resulted in remarkable progress and is currently affecting a paradigm shift in drug discovery and therapy development. PROTAC approach has allowed quick expansion of the “druggable proteome” beyond proteins that bear distinct functional sites […]
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  1. Biotech

BOC Sciences Optimizes PROTAC Platform to Boost Related Research

BOC Sciences optimizes its PROTAC platform of protein degradation technology to boost PROTAC research and development. PROTAC technology can not only transform non-drug targets into feasible drug targets but also resolve the problem of drug resistance of existing targets. Based on the upgraded PROTAC platform, BOC Sciences can optimize proteolysis targeting chimeric molecules, perform ligase engineering and […]
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  1. Biotech

BOC Sciences Updates Product List to Expand Access to Stable Isotope-Labeled Amino Acids

Stable isotope-labeled amino acids serve as safe, effective, and convenient tracer tools for scientific research in medicine, biology, pharmacy, chemistry, etc. As a leading manufacturer of isotope labeling compounds in isotope synthesis, BOC Sciences today upgraded its comprehensive list of stable isotope-labeled amino acids to help clients advance the related research.   To date, stable isotopes […]
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  1. Health

Keep Up with Frontier Breakthroughs? Register for the Webinar: Targeting RNA Structure as a Therapeutic Strategy

BOC Sciences has put its back into chemical and biochemical production for years while it also focuses on cutting-edge research in these fields. Lately, it projects a webinar themed as Targeting RNA Structure as a Therapeutic Strategy, awaiting broad participation on January 19th, 2022.   As a leading chemical and biochemical supplier, BOC Sciences seeks […]
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  1. Biotech

Keep Up with Frontier Breakthroughs? Register for the Webinar: Targeting RNA Structure as a Therapeutic Strategy

BOC Sciences has put its back into chemical and biochemical production for years while it also focuses on cutting-edge research in these fields. Lately, it projects a webinar themed as Targeting RNA Structure as a Therapeutic Strategy, awaiting broad participation on January 19th, 2022.   As a leading chemical and biochemical supplier, BOC Sciences seeks […]
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  1. Biotech

Keep Up with Frontier Breakthroughs? Register for the Webinar: Targeting RNA Structure as a Therapeutic Strategy

BOC Sciences has put its back into chemical and biochemical production for years while it also focuses on cutting-edge research in these fields. Lately, it projects a webinar themed as Targeting RNA Structure as a Therapeutic Strategy, awaiting broad participation on January 19th, 2022.   As a leading chemical and biochemical supplier, BOC Sciences seeks […]
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  1. Biotech

Keep Up with Frontier Breakthroughs? Register for the Webinar: Targeting RNA Structure as a Therapeutic Strategy

BOC Sciences has put its back into chemical and biochemical production for years while it also focuses on cutting-edge research in these fields. Lately, it projects a webinar themed as Targeting RNA Structure as a Therapeutic Strategy, awaiting broad participation on January 19th, 2022.   As a leading chemical and biochemical supplier, BOC Sciences seeks […]
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  1. Biotech

Keep Up with Frontier Breakthroughs? Register for the Webinar: Targeting RNA Structure as a Therapeutic Strategy

BOC Sciences has put its back into chemical and biochemical production for years while it also focuses on cutting-edge research in these fields. Lately, it projects a webinar themed as Targeting RNA Structure as a Therapeutic Strategy, awaiting broad participation on January 19th, 2022.   As a leading chemical and biochemical supplier, BOC Sciences seeks […]
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  1. Science / Technology

BOC Sciences: Professional Provider of GMP-Compliant Fermentation CDMO Services

BOC Sciences, an excellent contract development and manufacturing company, offers world-class fermentation CDMO services for global biotech, large pharmaceutical, and biopharmaceutical companies to develop various biomolecules and products.   As a fermentation contract development and manufacturing organization (CDMO), BOC Sciences, equipped with first-class fermentation capabilities, possesses complete fermentation and downstream processing facilities as well as rich […]
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  1. Biotech

AAPEP Provides Amino Acid Products for High-Level Biochemical Research

AAPEP, a sub-brand of BOC Sciences, is an experienced biochemistry company, which offers a complete range of amino acid products, including natural amino acids and unnatural amino acids, for chemical and biochemical laboratory and scientific use.   Proteins perform a series of remarkable functions with only 20 kinds of natural amino acids. However, these limited natural amino acids fail […]
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  1. Science / Technology

siRNA Drug Delivery Platform of BOC RNA Speeds Up Disease Treatment Research

BOC RNA, a sub-brand of BOC Sciences, has been contributing to the development of siRNA drug delivery system for years and provides a series of siRNA conjugates.   siRNA drugs demonstrate promising prospects in clinical practice. However, naked siRNA shows some defects due to the existence of plentiful RNases in the blood which will accelerate its degradation, thus reducing the efficacy […]
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  1. Biotech

BOC Sciences Proudly Declares High PseudoUridine Productivity

BOC Sciences, well known as the largest supplier of pseudoUridine in the world, announces that its yearly output currently surpasses 500 kg, indicating reliable efficiency and high productivity.   Along with the explosion of the COVID-19 pandemic, many vaccine companies have collaborated with BOC Sciences to obtain necessary materials such as pseudoUridine and its derivatives. PseudoUridine is universally acknowledged as […]
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BOC Sciences' Exhibition at TIDES USA 2021 Shows Its Strong PseudoUridine Productivity

From September 20 to 23, 2021, BOC Sciences, the leading manufacturer of pseudoUridine, participated in the industry‘s most well-known conference–TIDES USA 2021 in Boston, Massachusetts, demonstrating its strong production capacity of pseudoUridine. The TIDE USA, also known as Oligonucleotide & Peptide Therapeutics Conference, covers topics ranging from drug discovery, preclinical and clinical development, CMC, marketing of therapeutics and vaccines, oligonucleotides, peptides, […]
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BOC Sciences Provides PseudoUridines for Vaccine R&D

BOC Sciences, a vaccine raw material supplier headquartered in New York, announces providing pseudoUridine products for RNA modification to further promote the research and development of vaccines. According to BOC Sciences‘ latest report, its annual production of pseudoUridine (key raw material of vaccines) has ranked first in the world. Massive studies have shown that chemical modification of RNA would affect gene expression in RNA with […]
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Application of High-throughput Drug Screening in New Drug Development

The principle of high-throughput drug screening is that drugs mostly re-adjust the patient's physiological state by specifically acting on target proteins (receptors, enzymes, ion channels, etc.). High-throughput screening (HTS), using microplates containing compounds (such as enzymes and receptors) and cells as carriers, is a method for screening drug candidates that interact with a target protein […]
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