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One of the innovative therapy for desmoid tumors is the use of anti-hormonal agents. Estrogen has been implicated in the pathogenesis of Desmoid Tumors, as they commonly occur during or after pregnancy and are more prevalent in females. Selective estrogen receptor modulators (SERMs) such as tamoxifen and toremifene have demonstrated efficacy in controlling desmoid tumor growth by blocking the estrogen receptor. Additionally, aromatase inhibitors, such as letrozole, which inhibit estrogen production, have shown promise in reducing tumor size and symptoms associated with desmoid tumors. These hormonal therapies provide a non-invasive option for patients, particularly those who wish to preserve fertility or avoid surgery.
