Palbociclib is an inhibitor of cyclin-dependent kinases (CDK) 4 and 6. Cyclin D1 and CDK4/6 are downstream of signalling pathways which lead to cellular proliferation. Palbociclib is sold under the brand name Ibrance. This drug is used in treating HR-Positive, HER2-Negative advanced, and metastatic breast cancer. In vitro, palbociclib reduced cellular proliferation of estrogen receptor (ER)-positive breast cancer cell lines by blocking the progression of the cell from G1 into the S phase of the cell cycle. The drug Palbociclib is supplied in 75 mg, 100 mg and 125 mg capsules to administer orally via the mouth. The active ingredient in the capsules is Palbociclib, with inactive ingredients Microcrystalline cellulose, lactose monohydrate, sodium starch glycolate, colloidal silicon dioxide, magnesium stearate, and hard gelatin capsule shells. One should store the capsules at 68 °F to 77 °F (20 °C to 25 °C).
Ibrance cost is reasonable, and you can find this medication with several generic medicine suppliers. To know more about Palbociclib, call us on 18008891064.
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