The enterochromaffin cells found throughout the GI and bronchial tracts are the primary source of enteroid tumours (NETs), which are a type of NET.1,2 Many biologically active substances, such as serotonin, norepinephrine, dopamine, histamine, bradykinin, prostaglandins, substance P, and others, are produced, stored, and secreted by these cells, which may result in the development of carcinoid syndrome, a term used to describe a range of symptoms caused by the hormones secreted by the carcinoid tumour.
Somatostatin receptors (SSTRs) are widely expressed by well-differentiated NETs.1 SSTR1 and SSTR5 are the two SSTR types that synthetic somatostatin analogues (SSAs) specifically target. Serotonin is Carcinoid Syndrome Diarrhea Treatment by carcinoid tumours, which depletes tryptophan in the body.
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