Pharmaceutical company Bristol Myers Squibb announced promising results this week for its investigational BCMA (B-cell maturation antigen)-targeted CAR T-cell therapy, ElrexfioTM (elranatamab-bcmm), for the treatment of relapsed or refractory multiple myeloma.
Multiple myeloma is a type of blood cancer that affects plasma cells. Despite recent advances, it remains an incurable disease representing approximately 2% of all cancer deaths. Elrexfio is a potential new personalized immunotherapy that targets BCMA, a protein commonly overexpressed in multiple myeloma cells.
Findings from the phase 1/2 KarMMa-2 study showed that over 75% of heavily pretreated multiple myeloma patients achieved a response after a single infusion of Elrexfio. The overall response rate was 79%, with 25% achieving a complete response and 54% achieving a very good partial response or better. Responses deepened over time in most patients.
At a median follow-up time of 11.5 months, the median duration of response had not yet been reached, meaning most responders were still benefiting from treatment at the time of analysis. The safety profile was manageable and primarily consisted of the expected cytokine release syndrome and neurological events.
“These results suggest that Elrexfio could become an important new targeted BCMA CAR T-cell therapy for patients with relapsed and refractory multiple myeloma,” said study author Dr. Jesús Berdeja. “We are particularly encouraged to see the depth of responses improve over time.”
Bristol Myers Squibb plans to submit Elrexfio to regulatory authorities for approval based on these positive phase 2 results. If approved, this therapy would provide a new precision medicine option targeting BCMA for multiple myeloma patients in need.
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