The exact cause of this rare disorder, which affects 5-17 in 100,000 people, is unknown; however, a complex interplay between different risk factors, including age, genetics and environment, is likely to contribute to the onset of this rare tauopathy
London
Roots Analysis has announced the addition of “Progressive Supranuclear Palsy Therapies Market, 2021-2030” report to its list of offerings.
Presently, there is no cure for PSP and the effectiveness of prescribed generic medications and non-drug therapies to improve the quality of life in patients, is limited. The high unmet patient need and rising caregiver burden has inspired several players to focus their efforts on the development of therapies to control the progression of PSP or manage its symptoms. Consequently, multiple orphan designated drugs, currently in phase II of development, are anticipated to enter the market in the next 3-6 years.
To order this 100+ page report, which features 70+ figures, please visit https://www.rootsanalysis.com/reports/progressive-supranuclear-palsy-market.html
Key Market Insights
Currently, over 20 drugs are being developed across preclinical and clinical stages
Majority (50%) of the drug candidates are being evaluated in phase I clinical studies to ease the complexities associated with PSP. Further, owing to their ability to cross the blood-brain barrier, small molecule drugs represent ~70% of the PSP pipeline; this is followed by anti-tau antibodies and antisense oligonucleotides. Since majority of the drugs are small molecules, oral route is the most preferred route.
Close to 20 industry and non-industry players are engaged in the development of drugs for PSP
Majority of the industry players (59%) are small firms / start-ups (with less than 50 employees). North America is the current hub, where close to 60% players are based. Further, a few non-industry players, including Washington University and Scripps Research, are leading the development of several early- stage PSP programs.
More than 100 trials, related to PSP, were registered in the last two decades
It is worth mentioning that around 52% of the trials were / are being conducted in Europe and Asia-Pacific region, however, more than 60% of the patients are enrolled in clinical trials conducted in North America. Further, most of the studies are focused on investigating tau targeted radiopharmaceuticals for PSP.
Around 80 eminent scientists, clinicians and industry veterans, with specialization in neurobiology, emerged as key opinion leaders (KOLs), in this domain
Nearly 50% of these KOLs are associated with organizations based in Europe, followed by North America. Multiple individuals from University of California, San Francisco and Toulouse Hospital and University Center are involved in clinical studies for PSP drugs. Further, 76% of these KOLs have doctoral degrees, namely MD and PhD.
Grants worth over USD 300 million have been awarded to support PSP research, since 2010
Till July 2021, over 700 grants have been disbursed to various companies / organizations working in this domain. National Institute on Ageing and National Institute of Neurological Disorders and Stroke emerged as the most active funding institutes, contributing to over 90% of the total grant amount.
