Efficiency plays a key role when conducting clinical trials. As your company develops new pharmaceuticals, you want to move from one stage to another as smoothly as possible. When collecting data in early clinical development and preparing for manufacturing, there are many variables to consider. One of those variables is your drug delivery method during clinical trials. This detail can be overlooked in terms of variability but is essential when you want to collect high-quality data. If you’re developing a poorly soluble drug or supplement, the system of delivery makes a difference. Using tablets can produce different results when compared to liquid-filled capsules. You may even reduce the efficiency of your clinical trial by choosing one delivery method over another. Does this mean you should use liquid-filled capsules over other options? Here are some factors to consider.
The Clear Benefits of Liquid-Filled Capsules
When you work with a contract development and manufacturing organization, you get access to a variety of drug delivery methods. A comprehensive pharmaceutical CDMO can offer everything from powder-filled capsules to injectables, gels, and creams. Of course, each delivery method comes with its advantages and disadvantages. Not every system is suitable for every drug. When working with poorly soluble small molecules, you want to choose a delivery method that maximizes bioavailability and absorption, thus resulting in reliable data. Two-piece, hard-shell, liquid-filled capsules (LFCs) can help you achieve this. When you have a more efficient molecule delivery system, improved absorption, and improved data, you can expedite clinical trials and move to the next phase more quickly.
Liquid-Filled Capsules Offer Options
Another significant benefit of LFCs is the bevy of options they offer. You can adjust dosages on short notice, if necessary. LFCs can be filled with a variety of liquids, and the liquid can be aqueous or non-aqueous. You don’t need binders, lubricants, or plasticizers. The LFC can be used to deliver beads, micro tablets, or pellets. This allows you to combine certain drugs that may not be compatible in other forms into a single dosage. To top it all off, you also have a choice in the hard-shell capsule material. This includes gelatin-based options and plant-based polymers for vegetarian and vegan options. For new drug development, having a wide variety of options is essential. As you explore different combinations and dosages, LFCs can help you streamline the process.
Liquid-Filled Capsules Improve Consumer Safety and Boost Brand Identity
LFCs not only offer more options for your drug development project, but they’re also designed to improve consumer safety. This is thanks in part to the design of the capsule itself. It can be sealed in a way to prevent both leaking and tampering. This helps consumers build confidence in your brand as they use your new drug. Another design aspect of LFCs is brand contrast. The hard shell of the capsule can be customized using a variety of color additives. You have the option to make your new LFC stand out. It’s a marketing opportunity waiting to happen. Not only can the capsule be color customized, but the band used to seal the capsule can also be color customized.
About Altasciences
As a mid-sized contract research organization and drug development solution, Altasciences offers partners more than 25 years of research experience for preclinical studies and clinical trials. This full-service, integrated CRO/CDMO has developed an innovative approach to drug development and created a foundation pharmaceutical and biotechnology companies have come to rely on. Altasciences offers a fully qualified and FDA–inspected, cGMP manufacturing area capable of various dosage forms, to ensure your pharmaceutical contract manufacturing success. Clients also gain the Altasciences teams’ expertise in a wide variety of study types and therapeutic indications, including vast experience in first-in-human clinical trials, CNS clinical trials, ethnobridging, as well as bioanalytical services. Altasciences provides partners with access to dedicated Phase 1 clinical trial units across North America, both in the USA and Canada. Partners can utilize Altasciences’ resources, including access to over 580 beds, an experienced, highly trained staff, and a recruiting database of more than 400,000 potential participants. Partner with this trusted CRO/CDMO for all your early clinical development needs.
As you prepare for drug trials, explore the benefits of partnering with Altasciences at https://www.altasciences.com/
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